探寻BRCA1和BRCA2的肿瘤抑制功能。
In search of the tumour-suppressor functions of BRCA1 and BRCA2.
作者信息
Scully R, Livingston D M
机构信息
The Dana-Farber Cancer Institute and the Harvard Medical School, Boston, Massachusetts 02115, USA.
出版信息
Nature. 2000 Nov 23;408(6811):429-32. doi: 10.1038/35044000.
Abstract
Hereditary breast and ovarian cancer syndromes can be caused by loss-of-function germline mutations in one of two tumour-suppressor genes, BRCA1 and BRCA2 (ref. 1). Each gene product interacts with recombination/DNA repair proteins in pathways that participate in preserving intact chromosome structure. However, it is unclear to what extent such functions specifically suppress breast and ovarian cancer. Here we analyse what is known of BRCA gene function and highlight some unanswered questions in the field.
摘要
遗传性乳腺癌和卵巢癌综合征可能由两种肿瘤抑制基因BRCA1和BRCA2之一的功能丧失性种系突变引起（参考文献1）。每个基因产物在参与维持完整染色体结构的途径中与重组/DNA修复蛋白相互作用。然而，尚不清楚这些功能在多大程度上特异性地抑制乳腺癌和卵巢癌。在这里，我们分析了已知的BRCA基因功能，并强调了该领域一些未解决的问题。
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本文引用的文献
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DNA polymerase stalling, sister chromatid recombination and the BRCA genes.DNA聚合酶停滞、姐妹染色单体重组与BRCA基因
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Role of the tumor suppressor gene Brca1 in genetic stability and mammary gland tumor formation.肿瘤抑制基因Brca1在遗传稳定性和乳腺肿瘤形成中的作用。
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ATR disruption leads to chromosomal fragmentation and early embryonic lethality.ATR功能破坏会导致染色体断裂和早期胚胎致死。
Genes Dev. 2000 Feb 15;14(4):397-402.
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