Davis F A, Mohanty P K, Burns D M, Andemichael Y W
Department of Chemistry, Temple University, Philadelphia, Pennsylvania 19122, USA.
Org Lett. 2000 Nov 30;2(24):3901-3. doi: 10.1021/ol006654u.
[reaction: see text] The highly diastereoselective addition of lateral lithiated o-tolunitriles to sulfinimines followed by treatment of the resulting sulfinamide with MeLi, hydrolysis, and reduction represents a concise new methodology for the asymmetric synthesis of 1,3-disubstituted tetrahydroisoquinolines.
[反应：见正文] 间位锂化的邻甲苯腈与亚磺酰亚胺进行高度非对映选择性加成，然后将所得的亚磺酰胺用甲基锂处理、水解并还原，这代表了一种用于不对称合成1,3 - 二取代四氢异喹啉的简洁新方法。
