Encinas J A, Kuchroo V K
Bayer Yakuhin Limited, Research Center Kyoto, 6-5-1-3 Kunimidai, Kizu-cho, Soraku-gun, Kyoto 619-0216, Japan.
Curr Opin Immunol. 2000 Dec;12(6):691-7. doi: 10.1016/s0952-7915(00)00164-3.
Over the past several years, intense effort has been made to map the chromosomal locations of genes involved in the susceptibility to autoimmune diseases. The first phase of this mapping effort-performed in most cases by using microsatellite markers to scan the genome for loci that are linked with disease-has generated first-draft maps for numerous autoimmune diseases in humans, mice and rats, pointing to as many as 20 different loci in some diseases. The second phase is now beginning, with efforts focused on narrowing the loci sufficiently to allow the positional cloning of disease-associated alleles. From these mapping data it is clear that some of these loci overlap between various autoimmune diseases and preliminary results suggest that indeed there is a sharing of 'autoimmunity genes' between various autoimmune diseases.
在过去几年中，人们付出了巨大努力来绘制与自身免疫性疾病易感性相关基因的染色体位置图谱。这项图谱绘制工作的第一阶段——在大多数情况下，通过使用微卫星标记扫描基因组以寻找与疾病相关的位点——已经为人类、小鼠和大鼠的多种自身免疫性疾病生成了初稿图谱，在某些疾病中指出了多达20个不同的位点。第二阶段现已开始，工作重点是充分缩小这些位点的范围，以便对与疾病相关的等位基因进行定位克隆。从这些图谱数据可以清楚地看出，其中一些位点在各种自身免疫性疾病之间存在重叠，初步结果表明，各种自身免疫性疾病之间确实存在“自身免疫基因”的共享。
