Autoimmunity and Metabolism Unit, Department of Medicine, IRCCS Istituto Clinico Humanitas, Italy.
Autoimmun Rev. 2011 Oct;10(12):725-32. doi: 10.1016/j.autrev.2011.06.004. Epub 2011 Jul 6.
There is now growing evidence that autoimmunity is the common trait connecting multiple clinical phenotypes albeit differences in tissue specificity, pathogenetic mechanisms, and therapeutic approaches cannot be overlooked. Over the past years we witnessed a constant growth of the number of publications related to autoimmune diseases in peer-reviewed journals of the immunology area. Original data referred to factors from common injury pathways (i.e. T helper 17 cells, serum autoantibodies, or vitamin D) and specific diseases such as multiple sclerosis, systemic lupus erythematosus, and rheumatoid arthritis. As an example, the issue of a latitudinal gradient in the prevalence and incidence rates has been proposed for all autoimmune diseases and was recently coined as geoepidemiology to suggest new environmental triggers for tolerance breakdown. The present article is aimed at reviewing the articles that were published over the past year in the major autoimmunity and immunology journals.
现在有越来越多的证据表明，自身免疫是连接多种临床表型的共同特征，尽管不能忽视组织特异性、发病机制和治疗方法的差异。在过去的几年中，我们见证了免疫学领域同行评议期刊上与自身免疫性疾病相关的出版物数量不断增加。原始数据涉及到常见损伤途径的因素（例如 Th17 细胞、血清自身抗体或维生素 D）和特定疾病，如多发性硬化症、系统性红斑狼疮和类风湿关节炎。例如，自身免疫性疾病的患病率和发病率呈纬度梯度的问题已经提出，并最近被称为地理流行病学，以提示耐受破坏的新环境触发因素。本文旨在回顾过去一年在主要自身免疫和免疫学杂志上发表的文章。
