Tanaka T, Matsumura T, Iehara T, Sawada T
Department of Pediatrics and Division of Clinical Research, National Kure Hospital, Hiroshima, Japan.
Med Pediatr Oncol. 2000 Dec;35(6):705-7. doi: 10.1002/1096-911x(20001201)35:6<705::aid-mpo48>3.0.co;2-l.
Current study shows that about 50% of neuroblastomas (NBs) detected through mass screening had factor(s) indicating an unfavorable biological nature and that early intervention after the screening might improve clinical outcome of the patients. On the other hand, favorable properties were detected in the remaining half of the mass-screening NBs. Some of them might have the ability to regress spontaneously. Therapeutic modality should be determined according to their biological nature. Further investigation for their biologic properties is necessary to evaluate the benefits of the mass screening.
当前研究表明，通过大规模筛查检测出的神经母细胞瘤（NBs）中，约50%具有提示生物学特性不良的因素，筛查后的早期干预可能改善患者的临床结局。另一方面，在另一半大规模筛查的NBs中检测到了良好特性。其中一些可能具有自发消退的能力。治疗方式应根据其生物学特性来确定。有必要对其生物学特性进行进一步研究，以评估大规模筛查的益处。
