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[酒精性中毒性脂肪肝的治疗。使用肝维他(Hepavis)的安慰剂对照试验(作者译)]

[Treatment of alcoholic toxic fatty liver. A placebo-controlled trial with hepavis (author's transl)].

作者信息

Deynet G, Reimer F

出版信息

MMW Munch Med Wochenschr. 1979 Jun 15;121(24):831-2.

PMID:111085
Abstract

A placebo-controlled double-blind study of 30 patients with advanced chronic fatty liver was intended to show how far treatment with a liver preparation, in this case Hepavis, is superior to alcohol abstinence alone. Examination of the laboratory parameters, especially of gamma GT shows that treatment with Hepavis with simultaneous withdrawal of alcohol produces a rapid normalization or improvement of the laboratory findings and consequently an accelerated improvement in the course of the disease. This leads to the conclusion that the pathological activity of the liver cell is reduced more quickly by the constituents of Hepavis than without suitable therapy, and that a more favorable prognosis for the fatty liver as a potential precurser of cirrhosis is to be attained. Not only is elimination of the lipogenic factor, alcohol, essential in the treatment of fatty liver, but also treatment with hepatotropic substances.

摘要

一项针对30例晚期慢性脂肪肝患者的安慰剂对照双盲研究旨在表明,在这种情况下使用肝制剂(即肝维他)进行治疗比单纯戒酒优越到何种程度。对实验室参数的检查,尤其是γ-谷氨酰转肽酶的检查表明,使用肝维他并同时戒酒的治疗可使实验室检查结果迅速恢复正常或得到改善,从而加速疾病进程的改善。由此得出结论,与未进行适当治疗相比,肝维他的成分能更快降低肝细胞的病理活性,并且对于作为肝硬化潜在先兆的脂肪肝可获得更有利的预后。治疗脂肪肝不仅消除致脂因素酒精至关重要,使用亲肝物质进行治疗也同样重要。

相似文献

1
[Treatment of alcoholic toxic fatty liver. A placebo-controlled trial with hepavis (author's transl)].[酒精性中毒性脂肪肝的治疗。使用肝维他(Hepavis)的安慰剂对照试验(作者译)]
MMW Munch Med Wochenschr. 1979 Jun 15;121(24):831-2.
2
[Does Hepavis have value in the therapy of fatty liver caused by alcohol poisoning?].[肝维辛在酒精中毒性脂肪肝治疗中有价值吗?]
Z Gastroenterol. 1989 Feb;27(2):91-3.
3
[Reflections on medicamentous liver-therapy. Hepavis in medical practice].[药物性肝脏治疗的思考。医学实践中的肝得健]
Med Monatsschr. 1977 Jul;31(7):328-30.
4
[Clinical experience report on Hepavis].[关于Hepavis的临床经验报告]
Med Welt. 1980 Oct 17;31(42):1519-21.
5
[Clinical experience with the oral liver-therapeutic agent Hepavis].[口服肝脏治疗药物肝维他的临床经验]
Med Welt. 1976 Nov 12;27(46):2248-9.
6
[Treatment with Hepavis, a new cholerectically-active hepaticum. Experiences from an internal medicine profemoral practice].[使用新型利胆活性肝脏药物赫帕维斯进行治疗。来自内科股动脉治疗实践的经验]
Med Monatsschr. 1977 Nov;31(11):524-6.
7
[Repair, regeneration and metabolism of liver cells: a clinical report].[肝细胞的修复、再生与代谢:一份临床报告]
ZFA (Stuttgart). 1979 Apr 30;55(12):787-91.
8
Effect of short-term therapy with propylthiouracil in patients with alcoholic liver disease.丙硫氧嘧啶短期治疗对酒精性肝病患者的影响。
Gastroenterology. 1979 Jan;76(1):105-15.
9
[Controlled clinical trial of a new combination of phosphorylcholine, homocysteine-gamma-thiolactone and vitamin B 12 in the parenteral treatment of chronic hepatopathies].[磷酰胆碱、同型半胱氨酸-γ-硫内酯与维生素B12新组合用于慢性肝病胃肠外治疗的对照临床试验]
Clin Ter. 1974 Jun 30;69(6):549-60.
10
[Active therapeutic exercises in combination with vasoactive drug in intermittent claudication (author's transl)].间歇性跛行中主动治疗性运动联合血管活性药物(作者译)
MMW Munch Med Wochenschr. 1978 Jan 20;120(2-3):69-72.

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