Berk M
Department of Psychiatry, University of the Witwatersrand Medical School, Parktown, South Africa.
Int Clin Psychopharmacol. 2000 Aug;15 Suppl 2:S41-5. doi: 10.1097/00004850-200008002-00007.
The overlap between the depressive and anxiety disorders is extremely common. The introduction of the selective serotonin reuptake inhibitors (SSRIs) has, more than any other development, bridged the gap in terms of efficacy in both sets of disorders. A substantial body of data exists suggesting that the available SSRIs have substantial efficacy in anxiety symptoms co-occurring with depression. The clear utility of the SSRIs in disorders classified apart from depression is also established. Whilst panic disorder is the best studied, evidence on the efficacy of the SSRIs in disorders that previously did not attract much pharmacotherapeutic interest, such as social anxiety disorder and post-traumatic stress disorder is accumulating.
抑郁症和焦虑症之间的重叠极为常见。选择性5-羟色胺再摄取抑制剂（SSRI）的引入比其他任何进展都更有效地弥合了这两类疾病在疗效方面的差距。大量数据表明，现有的SSRI对伴有抑郁症的焦虑症状具有显著疗效。SSRI在与抑郁症分类不同的疾病中的明确效用也已得到证实。虽然惊恐障碍是研究得最充分的，但关于SSRI在社交焦虑障碍和创伤后应激障碍等以前未引起太多药物治疗关注的疾病中的疗效证据也在不断积累。
