Al-Humaidi M A
Department of Internal Medicine, King Saud University, College of Medicine, Abha, Kingdom of Saudi Arabia.
Ethn Dis. 2000 Autumn;10(3):350-6.
In order to predict the magnitude of coronary artery disease (CAD) among Saudi patients attending the primary health care centers (PHCCs), the probability of coronary artery disease (PCAD) was estimated for 696 subjects (50.4% males and 49.5% females), aged 30-70 years, by a computer model based on the Framingham Heart Study. The results indicated a high percentage of CAD risk factors, namely: hypercholesterolemia (31%); diabetes mellitus (30%); hypertension (13.8%); family history of CAD (6%); and obesity (45%). The estimated PCAD rates within 5, 10 and 12 years were 4.31%, 9.88%, and 12.25%, respectively. PCAD was significantly higher among males (P=.0001) and those with two or more CAD risk factors (P=.0001). A repeated measure analysis showed that there was a consistent relation between the overall PCAD rates at 5, 10 and 12 years, and a relationship between PCAD rates and other risk factors (eg, males had a higher risk of CAD than females). Likewise, individuals with two or more risk factors had a higher PCAD. The present study predicts an incremental scale of developing CAD in the Saudi population, which may lead to an upward trend on CAD mortality similar to that of the WHO MONICA populations of most countries in 1950 and early 1960s. The concept of preventive cardiology aiming at decreasing the prevalence of CAD risk factors should be implemented in all regions of Saudi Arabia in order to avoid the predicted upward trend of CAD mortality and to get a favorable decline of CAD risk factors and mortality similar to that in the United States and Australia.
为预测在初级卫生保健中心(PHCCs)就诊的沙特患者中冠状动脉疾病(CAD)的发病程度,基于弗雷明汉心脏研究,通过计算机模型对696名年龄在30至70岁的受试者(男性占50.4%,女性占49.5%)的冠状动脉疾病概率(PCAD)进行了估算。结果显示CAD危险因素的比例较高,即:高胆固醇血症(31%);糖尿病(30%);高血压(13.8%);CAD家族史(6%);以及肥胖(45%)。5年、10年和12年内估算的PCAD发生率分别为4.31%、9.88%和12.25%。男性以及有两个或更多CAD危险因素的人群中PCAD显著更高(P = 0.0001)。重复测量分析表明,5年、10年和12年的总体PCAD发生率之间存在一致关系,且PCAD发生率与其他危险因素之间也有关系(例如,男性患CAD的风险高于女性)。同样,有两个或更多危险因素的个体PCAD更高。本研究预测了沙特人群中CAD发病的递增规模,这可能导致CAD死亡率呈上升趋势,类似于20世纪50年代和60年代初大多数国家的世界卫生组织MONICA人群。为避免预测的CAD死亡率上升趋势,并使CAD危险因素和死亡率出现类似美国和澳大利亚那样的有利下降,沙特阿拉伯所有地区都应实施旨在降低CAD危险因素患病率的预防心脏病学理念。