谷胱甘肽S-转移酶基因的T null和M null基因型是冠心病的危险因素，与吸烟无关。
T null and M null genotypes of the glutathione S-transferase gene are risk factor for CAD independent of smoking.
作者信息
Abu-Amero Khaled K, Al-Boudari Olayan M, Mohamed Gamal H, Dzimiri Nduna
机构信息
Department of Genetics, King Faisal Specialist Hospital and Research Centre (MBC - 03), P. O. Box 3354, Riyadh 11211, Saudi Arabia.
出版信息
BMC Med Genet. 2006 Apr 19;7:38. doi: 10.1186/1471-2350-7-38.
BACKGROUND
The association of the deletion in GSTT1 and GSTM1 genes with coronary artery disease (CAD) among smokers is controversial. In addition, no such investigation has previously been conducted among Arabs.
METHODS
We genotyped 1054 CAD patients and 762 controls for GSTT1 and GSTM1 deletion by multiplex polymerase chain reaction. Both CAD and controls were Saudi Arabs.
RESULTS
In the control group (n = 762), 82.3% had the T wild M wildgenotype, 9% had the Twild M null, 2.4% had the Tnull M wild and 6.3% had the Tnull M null genotype. Among the CAD group (n = 1054), 29.5% had the Twild M wild genotype, 26.6% (p < .001) had the Twild M null, 8.3% (p < .001) had the Tnull M wild and 35.6% (p < .001) had the Tnull M null genotype, indicating a significant association of the Twild M null, Tnull M wild and Tnull M null genotypes with CAD. Univariate analysis also showed that smoking, age, hypercholesterolemia and hypertriglyceridemia, diabetes mellitus, family history of CAD, hypertension and obesity are all associated with CAD, whereas gender and myocardial infarction are not. Binary logistic regression for smoking and genotypes indicated that only M null and Tnullare interacting with smoking. However, further subgroup analysis stratifying the data by smoking status suggested that genotype-smoking interactions have no effect on the development of CAD.
CONCLUSION
GSTT1 and GSTM1 null-genotypes are risk factor for CAD independent of genotype-smoking interaction.
背景
吸烟者中谷胱甘肽S-转移酶T1（GSTT1）和谷胱甘肽S-转移酶M1（GSTM1）基因缺失与冠状动脉疾病（CAD）之间的关联存在争议。此外，此前尚未在阿拉伯人群中进行过此类调查。
方法
我们采用多重聚合酶链反应对1054例CAD患者和762例对照者进行GSTT1和GSTM1基因缺失的基因分型。CAD患者和对照者均为沙特阿拉伯人。
结果
在对照组（n = 762）中，82.3%具有T野生型M野生型基因型，9%具有T野生型M缺失型，2.4%具有T缺失型M野生型，6.3%具有T缺失型M缺失型基因型。在CAD组（n = 1054）中，29.5%具有T野生型M野生型基因型，26.6%（p <.001）具有T野生型M缺失型，8.3%（p <.001）具有T缺失型M野生型，35.6%（p <.001）具有T缺失型M缺失型基因型，表明T野生型M缺失型、T缺失型M野生型和T缺失型M缺失型基因型与CAD存在显著关联。单因素分析还显示，吸烟、年龄、高胆固醇血症和高甘油三酯血症、糖尿病、CAD家族史、高血压和肥胖均与CAD相关，而性别和心肌梗死则不然。吸烟与基因型的二元逻辑回归表明，只有M缺失型和T缺失型与吸烟存在交互作用。然而，进一步按吸烟状态对数据进行亚组分析表明，基因型-吸烟交互作用对CAD的发生发展没有影响。
结论
GSTT1和GSTM1基因缺失基因型是CAD的危险因素，与基因型-吸烟交互作用无关。
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