Bungo T, Ando R, Kawakami S, Ohgushi A, Shimojo M, Masuda Y, Furuse M
Laboratory of Feed Science, Department of Animal Science, Division of Animal and Marine Bioresources Science, Graduate School of Bioresource and Bioenvironmental Science, Kyushu University, Fukuoka 812-8581, Japan.
Physiol Behav. 2000 Sep 15;70(5):573-6. doi: 10.1016/s0031-9384(00)00301-2.
It is well known that central injection of bombesin (BN) suppresses feeding in mammalian and avian species, but the anorexigenic effect of central BN are still open with special reference to the chick. The dose response (0, 0.1 and 0.5 microg) of intracerebroventricular (ICV) injection of BN was examined in Experiment 1. ICV injection of BN inhibited food intake in a dose-dependent manner. Experiment 2 was done to determine whether BN interacts with the orexigenic effect of neuropeptide Y (NPY) in the neonatal chick. Central administration of NPY (2.5 microg) greatly enhanced food intake, but co-injection of BN (0.5 microg) suppressed food intake. The dose response of NPY (2.5 microg) co-injected with three levels of BN (0, 0.1 and 0.5 microg) was examined in Experiment 3. ICV injection of BN attenuated the hyperphagia by NPY in a dose-related fashion. It is suggested that central BN may interact with NPY for the regulation of feeding in the neonatal chick.
众所周知，向中枢注射蛙皮素（BN）会抑制哺乳动物和鸟类的进食，但中枢BN的厌食作用，尤其是对雏鸡而言，仍不明确。实验1检测了脑室内（ICV）注射BN的剂量反应（0、0.1和0.5微克）。ICV注射BN以剂量依赖的方式抑制食物摄入。实验2旨在确定BN是否与新生雏鸡中神经肽Y（NPY）的促食欲作用相互作用。中枢给予NPY（2.5微克）可大大增加食物摄入量，但同时注射BN（0.5微克）会抑制食物摄入。实验3检测了与三个水平的BN（0、0.1和0.5微克）共同注射的NPY（2.5微克）的剂量反应。ICV注射BN以剂量相关的方式减弱了NPY引起的摄食亢进。提示中枢BN可能与NPY相互作用以调节新生雏鸡的进食。
