Tachibana Tetsuya, Saito Shin, Tomonaga Shozo, Takagi Tomo, Saito Ei-Suke, Nakanishi Tomonori, Koutoku Tomoyuki, Tsukada Akira, Ohkubo Takeshi, Boswell Tim, Furuse Mitsuhiro
Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresource and Bioenvironmental Science, Kyushu University, Fukuoka 812-8581, Japan.
Physiol Behav. 2004 Feb;80(5):713-9. doi: 10.1016/j.physbeh.2003.12.005.
Prolactin-releasing peptide (PrRP) is one of the inhibitory factors in feeding regulation of mammals. However, no information is available for avian species. The present study was done to clarify the effect of intracerebroventricular (ICV) injection of PrRP on feeding in chicks. Firstly, we found that ICV injection of PrRP (94-1500 pmol) significantly increased food intake in chicks. The result was completely different from those obtained in mammals. The orexigenic effect of PrRP was significantly weaker than that of neuropeptide Y (NPY), a potent orexigenic peptide, on an equimolar basis. The orexigenic effect of NPY was further enhanced with coinjection of PrRP. These results suggest the existence of a novel orexigenic mechanism in the chick brain, which might differ from NPY-involved feeding regulatory pathway. In addition, ICV injection of PrRP significantly decreased the rectal temperature, but the effect was weaker than that of NPY, suggesting that PrRP may inhibit energy expenditure in chicks. Taken together, we showed here that PrRP may be involved in the regulation of both feeding behavior and energy metabolism in the chick brain.
催乳素释放肽（PrRP）是哺乳动物进食调节中的抑制因子之一。然而，关于鸟类的相关信息却尚无报道。本研究旨在阐明脑室内（ICV）注射PrRP对雏鸡进食的影响。首先，我们发现脑室内注射PrRP（94 - 1500皮摩尔）可显著增加雏鸡的采食量。这一结果与在哺乳动物中获得的结果完全不同。在等摩尔基础上，PrRP的促食欲作用明显弱于强效促食欲肽神经肽Y（NPY）。同时注射PrRP可进一步增强NPY的促食欲作用。这些结果表明雏鸡大脑中存在一种新的促食欲机制，这可能与涉及NPY的进食调节途径不同。此外，脑室内注射PrRP可显著降低直肠温度，但其作用弱于NPY，这表明PrRP可能抑制雏鸡的能量消耗。综上所述，我们在此表明PrRP可能参与雏鸡大脑中进食行为和能量代谢的调节。
Zotero 插件