白细胞去除对人CPDA - 1血液流变学特性的影响。
Effects of leucocyte depletion on rheologic properties of human CPDA-1 blood.
作者信息
Walter R, Brand B, Mark M, Schnyder L, Stifanic M, Reinhart W H
机构信息
Department of Internal Medicine, Kantonsspital, Chur, Switzerland.
出版信息
Vox Sang. 2000;79(3):151-5. doi: 10.1159/000031233.
BACKGROUND AND OBJECTIVES
Leucocyte depletion improves the quality of stored blood units. We have studied its role on blood viscosity.
MATERIALS AND METHODS
Viscosity of CPDA-1 blood units was measured in a Couette viscometer at shear rates of 94.5 and 0.1 s(-1) prior to and following filtration with the Leukotrap((R)) A1 system on day 0 and after 21 days at +4 degrees C.
RESULTS
On day 0, high but not low shear viscosity was significantly decreased. The red blood cell morphology was unaffected. On day 21, blood viscosity was increased similarly for unfiltered and filtered samples at both shear rates. The echinocytosis observed after storage correlated with the increase in viscosity.
CONCLUSION
Leucocyte depletion is associated with a decrease in high shear viscosity. This effect is, however, completely lost after 21 days.
背景与目的
白细胞去除可提高储存血液单位的质量。我们研究了其对血液粘度的作用。
材料与方法
在第0天以及在4℃下储存21天后，使用Leukotrap((R)) A1系统过滤之前和之后，在Couette粘度计中于94.5和0.1 s(-1)的剪切速率下测量CPDA-1血液单位的粘度。
结果
在第0天，高剪切粘度显著降低，但低剪切粘度未降低。红细胞形态未受影响。在第21天，未过滤和过滤后的样品在两种剪切速率下的血液粘度均有类似增加。储存后观察到的棘形红细胞增多与粘度增加相关。
结论
白细胞去除与高剪切粘度降低有关。然而，这种作用在21天后完全消失。
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