Erley C M, Bader B D
Abteilung Innere Medizin III, Universität Tübingen.
Rofo. 2000 Oct;172(10):791-7. doi: 10.1055/s-2000-7889.
The use of iodinated contrast media (CM) continues to be a common cause of hospital-acquired acute renal failure (ARF) and its development increases the in-hospital mortality significantly. Alterations in renal hemodynamics and direct tubular toxicity by contrast media are the primary factors believed to be responsible for contrast media-associated nephrotoxicity. We review recent insights into the pathogenesis of this complication and summarize prophylactic strategies focussing on hydration, vasoactive pharmacological agents, alternative contrast media and "prophylactic hemodialysis".
使用含碘造影剂（CM）仍然是医院获得性急性肾衰竭（ARF）的常见原因，其发生会显著增加住院死亡率。造影剂导致的肾血流动力学改变和直接肾小管毒性被认为是造影剂相关性肾毒性的主要因素。我们回顾了对这一并发症发病机制的最新见解，并总结了以水化、血管活性药物、替代造影剂和“预防性血液透析”为重点的预防策略。
