Vavić N, Dimković N, Mangovski Lj
Institute for Kidney Disease, Zvezdaa University Medical Centre, Belgrade.
Srp Arh Celok Lek. 1996;124 Suppl 1:138-9.
The widespread use of radio-opaque contrast media continues to be a common cause of renal injury in patients admitted to hospital. Renal damage after intravascular contrast media is seen clinically as an acute reduction of glomerular filtration rate varying from a relatively transient, asymptomatic course to the development of oliguric acute renal failure. Preexisting renal insufficiency and/or other risk factors such as diabetes mellitus, dehydration, paraproteinemia, hyperuricaemia, hypoalbuminaemia, and congestive heart failure, may increase the risk of nephrotoxicity and enhance renal damage. At the Institute for Kidney Disease Zvezdara University Medical Centre, Belgrad, we observed three patients who had renal damage after intravascular contrast media during 1993. All of the patients had various risk factors, particularly baseline renal insufficiency. In order to prevent or minimize renal failure after intravascular contrast media application, the authors recommended preventive measures including identification of risk patients, minimizing contrast volume and hydration.
不透射线造影剂的广泛使用仍是住院患者肾损伤的常见原因。血管内造影剂使用后的肾损害在临床上表现为肾小球滤过率急性降低，从相对短暂的无症状病程到少尿性急性肾衰竭的发展。既往存在的肾功能不全和/或其他危险因素，如糖尿病、脱水、副蛋白血症、高尿酸血症、低白蛋白血症和充血性心力衰竭，可能增加肾毒性风险并加重肾损害。在贝尔格莱德兹韦兹达拉大学医学中心肾病研究所，我们在1993年观察到3例血管内造影剂使用后发生肾损害的患者。所有患者都有各种危险因素，尤其是基线肾功能不全。为了预防或尽量减少血管内造影剂应用后的肾衰竭，作者推荐了包括识别高危患者、减少造影剂用量和水化在内的预防措施。
