Mullan S
Surg Neurol. 1975 Jan;3(1):27-32.
Antifibrinolytic drugs and subtotal occulusion of carotid artery have been investigated in a series of 168 patients with recently ruptured intracranial aneursyms. It is concluded that epsilon-aminocaproic acid offers effective treatment, that aggressive hypotensive therapy is dangerous in the severely obtunded patient, and that epsilon-aminocaproic acid plus subtotal carotid occlusion (supplemented by a moderate hypotensive regime) offer the best treatment, in this experience, in the prevention of recurrent hemmorrhages.
对168例近期颅内动脉瘤破裂患者进行了抗纤维蛋白溶解药物和颈动脉次全闭塞的研究。得出的结论是，ε-氨基己酸提供了有效的治疗方法，在严重昏迷的患者中积极的降压治疗是危险的，并且在本研究经验中，ε-氨基己酸加颈动脉次全闭塞（辅以适度的降压方案）提供了预防复发性出血的最佳治疗方法。
