细胞斯基林A和B，从一种内生真菌中分离出的新型具有生物活性的双蒽醌类化合物。
Cytoskyrins A and B, new BIA active bisanthraquinones isolated from an endophytic fungus.
作者信息
Brady S F, Singh M P, Janso J E, Clardy J
机构信息
Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, USA.
出版信息
Org Lett. 2000 Dec 14;2(25):4047-9. doi: 10.1021/ol006681k.
[structure] The biochemical induction assay (BIA) is a rapid (colorimetric) bacterial assay used to identify compounds that damage DNA or inhibit DNA synthesis and thereby identify potential natural product anticancer agents. Bisanthraquinones based on a 1,3,6, 8-tetrahydroxyanthraquinone-type carbon skeleton were isolated from an endophytic fungus and characterized by NMR and X-ray crystallography. Cytoskyrin A (1) is highly active in the biochemical induction assay, while the closely related cytoskyrin B (2) has no detectable activity in this assay.
[结构] 生化诱导测定法（BIA）是一种快速（比色法）细菌测定法，用于鉴定破坏DNA或抑制DNA合成的化合物，从而鉴定潜在的天然产物抗癌剂。从一种内生真菌中分离出基于1,3,6,8-四羟基蒽醌型碳骨架的双蒽醌，并通过核磁共振（NMR）和X射线晶体学进行表征。细胞霉素A（1）在生化诱导测定中具有高活性，而密切相关的细胞霉素B（2）在该测定中没有可检测到的活性。
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