环孢菌素，从一种内生真菌中分离出的新型八酮类抗生素。

The cytosporones, new octaketide antibiotics isolated from an endophytic fungus.

作者信息

Brady S F, Wagenaar M M, Singh M P, Janso J E, Clardy J

机构信息

Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, USA.

出版信息

Org Lett. 2000 Dec 14;2(25):4043-6. doi: 10.1021/ol006680s.

DOI:10.1021/ol006680s

PMID:11112639

Abstract

[structure] Organic extracts from cultures of endophytic fungi collected in the Guanacaste Conservation Area of Costa Rica were screened for antibiotic activity. Two endophytes CR200 (Cytospora sp.) and CR146 (Diaporthe sp.) were found to have potent antibiotic activity. Bioassay-guided fractionation of the extracts from these fungi led to the identification of cytosporones D and E, antibacterial active trihydroxybenzene lactones, and three related but inactive metabolites. The five new octaketides were characterized using X-ray crystallography and NMR.

摘要

[结构] 对在哥斯达黎加瓜纳卡斯特保护区采集的内生真菌培养物的有机提取物进行了抗生素活性筛选。发现两种内生真菌CR200（壳梭孢属）和CR146（间座壳属）具有强大的抗生素活性。对这些真菌提取物进行生物测定导向的分级分离，鉴定出了壳梭孢菌素D和E，即具有抗菌活性的三羟基苯内酯，以及三种相关但无活性的代谢产物。利用X射线晶体学和核磁共振对这五种新的八酮类化合物进行了表征。