Isberg R R, Barnes P
Howard Hughes Medical Institute and Dept Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111, USA.
J Cell Sci. 2001 Jan;114(Pt 1):21-28. doi: 10.1242/jcs.114.1.21.
Enteropathogenic Yersinia are gram-negative bacterial species that translocate from the lumen of the intestine and are able to grow within deep tissue sites. During the earliest stages of disease, the organism is able to bind integrin receptors that are presented on the apical surface of M cells in the intestine, which allows its internalization and subsequent translocation into regional lymph nodes. The primary integrin substrate is the outer-membrane protein invasin, which binds with extraordinarily high affinity to at least five different integrins that have the (beta)(1) chain. Bacterial uptake into host cells is modulated by the affinity of receptor-substrate interaction, receptor concentration and the ability of the substrate to aggregate target receptors.
肠道致病性耶尔森菌是革兰氏阴性细菌，可从肠腔转移并能在深部组织部位生长。在疾病的最早阶段，该生物体能够结合肠道M细胞顶端表面呈现的整合素受体，从而实现内化并随后转移至区域淋巴结。主要的整合素底物是外膜蛋白侵袭素，它以极高的亲和力与至少五种含有β1链的不同整合素结合。细菌进入宿主细胞受受体 - 底物相互作用的亲和力、受体浓度以及底物聚集靶受体能力的调节。
