Isberg R R
Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 02111.
Mol Microbiol. 1989 Oct;3(10):1449-53. doi: 10.1111/j.1365-2958.1989.tb00128.x.
The entry of enteropathogenic Yersinia into cultured mammalian cells has been studied in order to gain insight into the mechanism of bacterial penetration into host cells during infection. There exist at least three pathways for entry by Yersinia into mammalian cells, the most efficient of which is promoted by invasin, the product of the inv gene. Invasin is an outer membrane protein that attaches to a mammalian cell receptor, initiating the entry process. Several receptors that bind invasin have been identified, and each is a member of the VLA family of integrin cell adhesion molecules. The role of integrins in the entry process is discussed, as is the ability of invasin to stimulate uptake by binding to its integrin receptor.
为深入了解感染过程中细菌侵入宿主细胞的机制，人们对致病性耶尔森菌进入培养的哺乳动物细胞的过程进行了研究。耶尔森菌进入哺乳动物细胞至少有三条途径，其中最有效的途径是由inv基因产物侵袭素介导的。侵袭素是一种外膜蛋白，它附着于哺乳动物细胞受体，启动进入过程。已鉴定出几种与侵袭素结合的受体，它们均为整联蛋白细胞粘附分子VLA家族的成员。本文讨论了整联蛋白在进入过程中的作用，以及侵袭素通过与其整联蛋白受体结合来刺激摄取的能力。
