Fliegelman L J, Friedland D, Brandwein M, Rothschild M
Mount Sinai School of Medicine, Department of Otolaryngology, New York, NY 10029, USA.
Otolaryngol Head Neck Surg. 2000 Dec;123(6):706-10. doi: 10.1067/mhn.2000.110963.
Although lymphatic malformations are often found to be well circumscribed when surgery is undertaken in early childhood, complete surgical excision can be difficult when the lesion is infiltrative. This study retrospectively evaluates these patients in an attempt to identify prognostic factors that may predict recurrence.
A retrospective chart review was conducted covering the years 1991 to 1998. Seventeen patients were identified having undergone 32 surgical resections of tumors described as lymphatic malformations. Data abstracted from the charts included the site of the lesion, surgical and histologic assessment of encapsulation, and status at follow-up examination.
Six of 17 patients developed a recurrence after surgery. Correlation between recurrence and histologic or operative impressions of encapsulation was significant by chi(2) analysis (P<0.01).
On the basis of the findings of this case series, lymphatic malformations that are found to be nonencapsulated and infiltrative by intraoperative or histologic assessment are more likely to recur.
尽管在幼儿期进行手术时，淋巴管畸形通常边界清晰，但当病变具有浸润性时，完整的手术切除可能会很困难。本研究对这些患者进行回顾性评估，试图确定可能预测复发的预后因素。
对1991年至1998年期间进行了回顾性病历审查。确定了17例患者，他们接受了32次被描述为淋巴管畸形的肿瘤手术切除。从病历中提取的数据包括病变部位、手术和组织学对包膜的评估以及随访检查时的状况。
17例患者中有6例术后复发。通过卡方分析，复发与组织学或手术对包膜的印象之间的相关性具有显著性（P<0.01）。
根据本病例系列的研究结果，术中或组织学评估发现为无包膜且具有浸润性的淋巴管畸形更有可能复发。
