Lei Zhi-Min, Huang Xing-Xing, Sun Zhi-Jun, Zhang Wen-Feng, Zhao Yi-Fang
Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University, Wuhan, People's Republic of China.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 Sep;104(3):338-44. doi: 10.1016/j.tripleo.2006.12.025. Epub 2007 Apr 11.
The objective of this study was to determine prognostic factors and complication rates related to the surgical management of lymphatic malformations of oral and cervicofacial regions in children.
The charts of 117 children operated on for oral and cervicofacial lymphatic malformations were retrospectively reviewed. Treatment outcomes were analyzed for correlation with several factors, including age at presentation, sex, associated symptoms, anatomical site of involvement, extent of disease, operative complications, histological pattern, and recurrence. The chi(2) test was used to compare treatment failure rates and complication rates between patients with and without these factors.
The tongue was the most frequent site of involvement (40.17%). The lesions with oral and facial involvement had a higher failure or recurrence rate (29.23%) than those with cervical involvement (8.33%; P < .05), and lesions with involvement of multiple sites had a higher recurrence rate (48.28%) than those with involvement of a single site or 2 sites (11.67%; P < .01). Although patients who underwent surgical procedure at less than 1 year of age had a higher recurrence rate (28.95%) than those more than 1 year (19.61%) of age, and microcystic lesions had a higher recurrence rate (28.33%) than macrocystic lesions (13.79%), no significant difference was found between them (P > .05). The lesions with involvement of 3 or more sites had significantly higher operative complication rates (37.8%) than those with involvement of 1 or 2 sites (15.58%; P < .01).
Factors correlated with a worse prognosis in lymphatic malformations of oral and cervicofacial regions include the involvement of the oral cavity and/or face and involvement of multiple anatomical sites, which also may be associated with higher operative complications.
本研究的目的是确定与儿童口腔颌面部淋巴管畸形手术治疗相关的预后因素和并发症发生率。
对117例接受口腔颌面部淋巴管畸形手术的儿童病历进行回顾性分析。分析治疗结果与几个因素的相关性，包括就诊年龄、性别、相关症状、受累解剖部位、疾病范围、手术并发症、组织学类型和复发情况。采用卡方检验比较有或无这些因素的患者之间的治疗失败率和并发症发生率。
舌是最常受累的部位（40.17%）。累及口腔和面部的病变比累及颈部的病变有更高的失败或复发率（29.23%比8.33%；P < 0.05），累及多个部位的病变比累及单个或两个部位的病变有更高的复发率（48.28%比11.67%；P < 0.01）。虽然1岁以下接受手术的患者比1岁以上患者有更高的复发率（28.95%比19.61%），微囊型病变比大囊型病变有更高的复发率（28.33%比13.79%），但两者之间无显著差异（P > 0.05）。累及3个或更多部位的病变比累及1个或2个部位的病变有显著更高的手术并发症发生率（37.8%比15.58%；P < 0.01）。
与口腔颌面部淋巴管畸形预后较差相关的因素包括口腔和/或面部受累以及多个解剖部位受累，这也可能与更高的手术并发症相关。
