Finelli L A, Baumann H, Borbély A A, Achermann P
Institute of Pharmacology and Toxicology, University of Zürich, Winterthurerstrasse 190, CH-8057, Zürich, Switzerland.
Neuroscience. 2000;101(3):523-9. doi: 10.1016/s0306-4522(00)00409-7.
To investigate the relationship between markers of sleep homeostasis during waking and sleep, the electroencephalogram of eight young males was recorded intermittently during a 40-h waking episode, as well as during baseline and recovery sleep. In the course of extended waking, spectral power of the electroencephalogram in the 5-8Hz band (theta activity) increased. In non-rapid eye movement sleep, power in the 0.75-4.5Hz band (slow-wave activity) was enhanced in the recovery night relative to baseline. Comparison of individual records revealed a positive correlation between the rise rate of theta activity during waking and the increase in slow-wave activity in the first non-rapid eye movement sleep episode. A topographic analysis based on 27 derivations showed that both effects were largest in frontal areas. From these results, we suggest that theta activity in waking and slow-wave activity in sleep are markers of a common homeostatic sleep process.
为了研究清醒和睡眠期间睡眠稳态标志物之间的关系，在一次40小时的清醒期间以及基线睡眠和恢复睡眠期间，对8名年轻男性的脑电图进行了间歇性记录。在长时间清醒过程中，脑电图在5-8Hz频段（θ活动）的频谱功率增加。在非快速眼动睡眠中，与基线相比，恢复夜间0.75-4.5Hz频段（慢波活动）的功率增强。个体记录的比较显示，清醒期间θ活动的上升速率与第一个非快速眼动睡眠阶段慢波活动的增加之间存在正相关。基于27个导联的地形分析表明，这两种效应在额叶区域最大。从这些结果来看，我们认为清醒时的θ活动和睡眠时的慢波活动是共同的睡眠稳态过程的标志物。
