Lammas D A, Drysdale P, Ben-Smith A, Girdlestone J, Edgar D, Kumararatne D S
MRC Centre for Immune Regulation, University of Birmingham, B15 2TT, Birmingham, UK.
Microbes Infect. 2000 Nov;2(13):1567-78. doi: 10.1016/s1286-4579(00)01313-7.
Patients with inherited defects in the interleukin-12 (IL-12)-dependent, 'high-output' interferon-gamma (IFN-gamma) pathway exhibit selective susceptibility to poorly pathogenic mycobacterial and salmonella infections. This review summarises the extended clinical spectrum seen in this group of patients and indicates a strategy for the identification of putative defects in the type 1 cytokine pathway.
白细胞介素-12（IL-12）依赖的“高产量”γ干扰素（IFN-γ）途径存在遗传性缺陷的患者，对致病性较弱的分枝杆菌和沙门氏菌感染表现出选择性易感性。本综述总结了在这组患者中观察到的扩展临床谱，并指出了一种识别1型细胞因子途径中假定缺陷的策略。
