Holland S M
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 10, 11N103, 10 Center Dr., MSC 1886, Bethesda, MD 20892-1886, USA.
Microbes Infect. 2000 Nov;2(13):1579-90. doi: 10.1016/s1286-4579(00)01314-9.
Cytokines are increasingly used for the therapy of infections in patient populations with special defects in immunity (chemotherapy, bone marrow transplantation, chronic granulomatous disease). The recognition of multiple defects in the systems of the interferon-gamma (IFN-gamma) receptor, interleukin-12 (IL-12) receptor and IL-12 p40 emphasizes the critical roles that cytokines play in preventing and clearing infection. The cases of patients with partially responsive IFN-gamma receptors (autosomal dominant and partial defects) are ideal candidates for successful cytokine prophylaxis and therapy. Better understanding of the critical elements of the cytokine pathways may show us ways to circumvent these defects with complementary cytokine cascades.
细胞因子越来越多地用于治疗免疫功能存在特殊缺陷的患者群体中的感染（化疗、骨髓移植、慢性肉芽肿病）。对干扰素-γ（IFN-γ）受体、白细胞介素-12（IL-12）受体和IL-12 p40系统中多种缺陷的认识，凸显了细胞因子在预防和清除感染中所起的关键作用。干扰素-γ受体部分反应性患者（常染色体显性和部分缺陷）的病例是细胞因子预防性治疗和治疗成功的理想候选者。更好地理解细胞因子途径的关键要素，可能会为我们指明通过互补细胞因子级联反应来规避这些缺陷的方法。
