地西泮可诱导海马体和纹状体中的成纤维细胞生长因子-2（FGF-2）信使核糖核酸（mRNA）的产生。
Diazepam induces FGF-2 mRNA in the hippocampus and striatum.
作者信息
Gómez-Pinilla F, Dao L, Choi J, Ryba E A
机构信息
Department of Physiological Science, University of California, Los Angeles, Los Angeles, CA 90095, USA.
出版信息
Brain Res Bull. 2000 Oct;53(3):283-9. doi: 10.1016/s0361-9230(00)00342-7.
starting by 6 h following diazepam injection and returning to approximately control values by 24 h. In situ hybridization showed elevated FGF-2 mRNA labeling in the hippocampal formation, mostly in the pyramidal layer of the CA1 and CA2 subfields and in the dentate gyrus hilar region. These results indicate that diazepam treatment up-regulates FGF-2 expression in select regions of the brain and suggest that GABA may promote neuroplasticity in concert with FGF-2.
从地西泮注射后6小时开始，到24小时时恢复到大致对照值。原位杂交显示海马结构中FGF - 2 mRNA标记升高，主要在CA1和CA2亚区的锥体细胞层以及齿状回门区。这些结果表明地西泮治疗上调了大脑特定区域的FGF - 2表达，并提示GABA可能与FGF - 2协同促进神经可塑性。
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