Pimentel E, Cruces M P, Zimmering S
Departamento de Genetica, Instituto Nacional de Investigaciones Nucleares, (ININ), Edo. de Mexico, Salazar, Mexico.
Mutat Res. 2000 Dec 20;472(1-2):71-4. doi: 10.1016/s1383-5718(00)00125-x.
Irradiation of 96h old Drosophila following a 24h pretreatment with 5% chlorophyllin (CHLN) was delayed 0-4 days. The antimutagenic effect of CHLN in somatic cells monitored by the wing spot test persisted for 3 days after completion of the pretreatment and appeared to terminate at a time corresponding to the cessation of mitotic divisions of wing anlagen cells. Within the same population of cells, CHLN demonstrated both an inhibitory effect as measured in mwh single spot classes, and contrarily, a promoting effect in the class of mwh/flr twin spots and to an extent in the class of large flr spots. The reason for the contrasting effects of CHLN remains to be determined.
用5%叶绿酸（CHLN）进行24小时预处理后，对96小时龄的果蝇进行辐照，辐照延迟了0至4天。通过翅斑试验监测，CHLN在体细胞中的抗诱变作用在预处理完成后持续3天，并且似乎在与翅原基细胞有丝分裂停止相对应的时间终止。在同一细胞群体中，CHLN在mwh单斑类别中表现出抑制作用，相反，在mwh/flr双斑类别中表现出促进作用，在大flr斑类别中也有一定程度的促进作用。CHLN产生相反作用的原因仍有待确定。
