睾酮去势水平定义的重新评估：对临床决策的影响
Reassessment of the definition of castrate levels of testosterone: implications for clinical decision making.
作者信息
Oefelein M G, Feng A, Scolieri M J, Ricchiutti D, Resnick M I
机构信息
University Hospitals of Cleveland, Department of Urology/Case Western Reserve University, Cleveland, Ohio, USA.
出版信息
Urology. 2000 Dec 20;56(6):1021-4. doi: 10.1016/s0090-4295(00)00793-7.
OBJECTIVES
Based on methods introduced in the late 1960s and no longer used, serum testosterone level in men after surgical castration was reported to be 50 ng/dL or less. Radioimmunoassay and, subsequently, chemiluminescent methods have supplanted the early analytic methods because of their improved accuracy and ease of testing. The purpose of this study was to define the castrate testosterone level in the era of chemiluminescent testing.
METHODS
After bilateral orchiectomy, serum testosterone (total) levels were measured prospectively in 35 prostate cancer patients.
RESULTS
The median testosterone value in this patient cohort was 15 ng/dL (0.5 nmol/L; 95% confidence interval 12 to 17 ng/dL).
CONCLUSIONS
In a contemporary series, castrate testosterone should be defined as less than 20 ng/dL (0.7 nmol/L). The important biologic and economic implications are discussed.
目的
基于20世纪60年代末引入且已不再使用的方法，据报道，手术去势后的男性血清睾酮水平为50 ng/dL或更低。放射免疫测定法以及随后的化学发光法因其更高的准确性和测试便利性，已取代了早期的分析方法。本研究的目的是确定化学发光检测时代的去势睾酮水平。
方法
对35例前列腺癌患者在双侧睾丸切除术后进行前瞻性血清总睾酮水平测定。
结果
该患者队列中的睾酮中位数为15 ng/dL（0.5 nmol/L；95%置信区间为12至17 ng/dL）。
结论
在当代系列研究中，去势睾酮应定义为低于20 ng/dL（0.7 nmol/L）。讨论了其重要的生物学和经济意义。
Zotero 插件