Klemm Jakob, von Deimling Markus, Fisch Margit, Kramer Gero, Tilki Derya, Steuber Thomas, von Amsberg Gunhild, Hengstenberg Christian, Shariat Shahrokh F
Klinik für Urologie, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Deutschland.
Klinik für Urologie, Comprehensive Cancer Center, Medizinische Universität Wien, Wien, Österreich.
Urologie. 2024 Mar;63(3):262-268. doi: 10.1007/s00120-023-02222-1. Epub 2023 Oct 24.
Prostate cancer is the most common malignancy in men, mostly affecting older men who harbor an increased prevalence of cardiovascular disease and metabolic syndrome. Androgen deprivation therapy (ADT), the standard therapy for various stages of prostate cancer, further increases the risk for cardiovascular disease and for metabolic syndrome. Therefore, screening for cardiovascular risk factors should be performed prior to the initiation of ADT, and, if necessary, cardiological evaluation and interdisciplinary management should be provided during and after completion of ADT. Moreover, the use of a gonadotropin-releasing hormone (GnRH) antagonist may help reduce cardiovascular risk in patients with cardiovascular disease.
前列腺癌是男性中最常见的恶性肿瘤，主要影响患有心血管疾病和代谢综合征患病率增加的老年男性。雄激素剥夺疗法（ADT）是前列腺癌各阶段的标准疗法，会进一步增加心血管疾病和代谢综合征的风险。因此，应在开始ADT之前进行心血管危险因素筛查，如有必要，在ADT期间及完成后应提供心脏科评估和多学科管理。此外，使用促性腺激素释放激素（GnRH）拮抗剂可能有助于降低患有心血管疾病患者的心血管风险。
