含免疫受体酪氨酸激活基序的跨膜衔接蛋白DAP12在淋巴细胞和髓细胞功能中的作用
The ITAM-bearing transmembrane adaptor DAP12 in lymphoid and myeloid cell function.
作者信息
Lanier L L, Bakker A B
机构信息
Dept of Microbiology and Immunology and the Cancer Research Institute, University of California San Francisco, 513 Parnassus Avenue, Box 0414, San Francisco, CA 94143-0414, USA.
出版信息
Immunol Today. 2000 Dec;21(12):611-4. doi: 10.1016/s0167-5699(00)01745-x.
DAP12, an ITAM-bearing transmembrane adaptor protein, associates non-covalently with receptors in natural killer (NK) and myeloid cells, and provides signaling function via the Syk and ZAP-70 tyrosine kinase activation pathways. Humans and mice lacking DAP12 (DAP12(-/-)) show normal development of hematopoietic cells. However, DAP12(-/-) humans develop presenile dementia and bone cysts, and DAP12(-/-) mice show impaired immune responses.
DAP12是一种含有免疫受体酪氨酸激活基序（ITAM）的跨膜衔接蛋白，它在自然杀伤（NK）细胞和髓细胞中与受体非共价结合，并通过Syk和ZAP-70酪氨酸激酶激活途径发挥信号传导功能。缺乏DAP12（DAP12-/-）的人类和小鼠造血细胞发育正常。然而，DAP12-/-的人类会患上早老性痴呆症和骨囊肿，而DAP12-/-的小鼠则表现出免疫反应受损。
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