Hamerman Jessica A, Lanier Lewis L
Department of Microbiology and Immunology, Cancer Research Institute, University of California, Box 0414, HSE1001, San Francisco, CA 94143-0414, USA.
Sci STKE. 2006 Jan 31;2006(320):re1. doi: 10.1126/stke.3202006re1.
Cells of the immune system possess many multisubunit receptors that are composed of a ligand-binding subunit associated with distinct signaling adaptors containing one or more immunoreceptor tyrosine-based activation motifs (ITAMs). These receptors include the T cell receptor, the B cell receptor, and many Fc receptors, as well as families of activating receptors on myeloid and natural killer cells. Receptors that associate with ITAM-containing adaptors classically have been viewed as transducing activating signals involving phosphorylation of the tyrosines within the ITAM and recruitment of Syk family tyrosine kinases. Receptors associated with ITAM-containing adaptors in myeloid cells have also been implicated in inhibition of cellular activation. Here, we discuss these new negative roles for signaling by receptors that associate with ITAM-bearing adaptors in myeloid and other cell types within the immune system.
免疫系统的细胞拥有许多多亚基受体，这些受体由一个配体结合亚基与不同的信号转导衔接子组成，这些衔接子包含一个或多个基于免疫受体酪氨酸的激活基序（ITAM）。这些受体包括T细胞受体、B细胞受体和许多Fc受体，以及髓系细胞和自然杀伤细胞上的激活受体家族。传统上，与含ITAM衔接子相关的受体被视为转导激活信号，涉及ITAM内酪氨酸的磷酸化以及Syk家族酪氨酸激酶的募集。髓系细胞中与含ITAM衔接子相关的受体也与细胞激活的抑制有关。在这里，我们讨论了与含ITAM衔接子相关的受体在免疫系统中的髓系细胞和其他细胞类型中信号传导的这些新的负性作用。
