热损伤后的凝血动力学：肝素和硫酸鱼精蛋白的作用
Coagulation dynamics following thermal injury: effect of heparin and protamine sulfate.
作者信息
Curreri P W, Wilterdink M E, Baxter C R
出版信息
Ann Surg. 1975 Feb;181(2):161-3. doi: 10.1097/00000658-197502000-00006.
Abstract
A burned rat model was developed to examine post-burn alterations in coagulation. Fibrin split product concentration, as measured by the staphylococcal clumping test, was noted to rise significantly within the first 24 hours following injury. Prophylactic in vivo systemic anticoagulation with heparin was ineffective in modifying this response. However, systemic administration of protamine sulfate prevented post-burn elevation of fibrin split products. In vitro fibrin split product concentration in burn sera following the addition of heparin and protamine sulfate, was also analyzed. The results of these experiments elucidated the biochemical effects of protamine sulfate on circulating fibrin degradation products in the rat burn model.
摘要
建立了烧伤大鼠模型以研究烧伤后凝血功能的变化。通过葡萄球菌凝集试验测定的纤维蛋白降解产物浓度在受伤后的最初24小时内显著升高。用肝素进行预防性体内全身抗凝对改变这种反应无效。然而，全身给予硫酸鱼精蛋白可防止烧伤后纤维蛋白降解产物升高。还分析了加入肝素和硫酸鱼精蛋白后烧伤血清中的体外纤维蛋白降解产物浓度。这些实验结果阐明了硫酸鱼精蛋白对大鼠烧伤模型中循环纤维蛋白降解产物的生化作用。
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Advances in fluid therapy and the early care of the burn patient.
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A new method for the determination of fibrinogen in small samples of plasma.一种测定少量血浆样本中纤维蛋白原的新方法。
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