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烧伤患者凝血异常的监测与治疗。当前实践的国际调查。

Monitoring and treatment of coagulation abnormalities in burn patients. an international survey on current practices.

作者信息

Lavrentieva A, Depetris N, Kaimakamis E, Berardino M, Stella M

机构信息

Burn ICU, Papanikolaou Hospital, Thessaloniki, Greece.

Anaesthesia and ICU - Orthopaedic and Trauma Centre A.O., Città della Salute e della Scienza, Turin, Italy.

出版信息

Ann Burns Fire Disasters. 2016 Sep 30;29(3):172-177.

Abstract

The magnitude of coagulation abnormalities, and the definition and treatment of coagulopathy in burn patients are inadequately understood and continue to be discussed in the literature. We aimed to analyse physicians' views on monitoring and treating coagulation abnormalities in burn patients. A total of 350 questionnaires were distributed electronically to burn ICU physicians. Participation was voluntary and anonymous. Responses were analysed electronically and comparisons were made according to the region of the ICU or the specialty of the physician. Of the 350 questionnaires distributed, 55 (15.7%) were returned. The majority of burn specialists consider sepsis-induced coagulopathy to be the most frequent coagulopathy in burn patients, and 74.5% declare that they do not use any specific definition/scoring system in their department to detect coagulopathy. The majority of specialists (70.8%) use standard coagulation tests. The most frequent indications for plasma transfusion are massive bleeding (32.8%) and Disseminated Intravascular Coagulation syndrome treatment (20%). The main specific factors reported in our study are cryoprecipitate (23.2%) and fibrinogen concentrate (18.9%). 21.1% of respondents state that they do not use any specific coagulation factor substitution in burn patients. Specific coagulation factor substitution is not a routine practice. The low response rate precludes the generalization of our results.

摘要

烧伤患者凝血异常的严重程度以及凝血病的定义和治疗尚未得到充分理解,相关内容仍在文献中讨论。我们旨在分析医生对烧伤患者凝血异常监测和治疗的看法。通过电子方式向烧伤重症监护病房的医生发放了总共350份问卷。参与是自愿且匿名的。对回复进行电子分析,并根据重症监护病房的区域或医生的专业进行比较。在发放的350份问卷中,有55份(15.7%)被退回。大多数烧伤专家认为脓毒症诱导的凝血病是烧伤患者中最常见的凝血病,74.5%的专家表示他们所在科室没有使用任何特定的定义/评分系统来检测凝血病。大多数专家(70.8%)使用标准凝血试验。输血的最常见指征是大出血(32.8%)和治疗弥散性血管内凝血综合征(20%)。我们研究中报告的主要特定因素是冷沉淀(23.2%)和纤维蛋白原浓缩物(18.9%)。21.1%的受访者表示他们在烧伤患者中不使用任何特定的凝血因子替代物。特定凝血因子替代并非常规做法。低回复率妨碍了我们结果的推广。

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