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经颅磁刺激治疗后耐药性抑郁症患者的局部脑血流变化：一项统计参数映射分析

Regional cerebral blood flow changes in drug-resistant depressed patients following treatment with transcranial magnetic stimulation: a statistical parametric mapping analysis.

作者信息

Zheng X M

机构信息

School of Clinical Sciences, Faculty of Health Studies, Charles Sturt University, Locked Bag 588, NSW 2678, Wagga Wagga, Australia.

出版信息

Psychiatry Res. 2000 Dec 4;100(2):75-80. doi: 10.1016/s0925-4927(00)00073-1.

DOI:10.1016/s0925-4927(00)00073-1
PMID:11114493
Abstract

Changes of regional cerebral blood flow (rCBF) in five drug-resistant depressed patients were examined by single photon emission computed tomography (SPECT) with 99mTc-hexamethylpropyleneamine oxime (99mTc-HMPAO) before and after treatment with transcranial magnetic stimulation (TMS). The SPECT images were analysed with the Statistical Parametric Mapping (SPM) package. TMS administered in the region of the left dorsolateral prefrontal cortex (DLPFC) of the depressed patients was associated with an increase of rCBF at a focal region some distance from the stimulation site. No change was observed at any other remote region.

摘要

采用单光子发射计算机断层扫描（SPECT）及99m锝-六甲基丙烯胺肟（99mTc-HMPAO），对5例耐药性抑郁症患者在经颅磁刺激（TMS）治疗前后的局部脑血流量（rCBF）变化进行了检查。使用统计参数映射（SPM）软件包对SPECT图像进行分析。对抑郁症患者左侧背外侧前额叶皮质（DLPFC）区域进行TMS治疗后，在距刺激部位一定距离的局部区域rCBF增加。在其他任何远程区域均未观察到变化。

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