Voitk A J, Crispin J S
Ann Surg. 1975 Feb;181(2):220-5. doi: 10.1097/00000658-197502000-00017.
85% enterectomy or jejunal biopsy was randomly carried out on 80 male Sprague-Dawley rats, 300-350 gm. After recovery, rats in each group were randomly fed either elemental diet (ED) or rat chow. All rats were sacrificed 8 weeks postoperatively. Biopsied rats gained more weight with ED than chow (22% vs. 18%; p less than .01). Resection produced greater weight loss than biopsy (p less than .01) and slower gain (p less than .01). The failure to gain was most marked in ED rats, significantly less than in the chow group (p less than .05) by week two. A fall in hemoglobin, protein and albumin was seen: neither the fall nor difference between the groups was significant (p greater than .05). Enterectomized chow rats ate 22% more than their controls (p greater than .05). Increase in bowel length after resection, equally divided between jejunum and ileum, was 21% with ED and 26% with chow. Gut diameter after resection increased 104% and 98% with chow and ED, respectively. Villus height increased 65% in the jejunum of both enterectomized groups and 85% and 78% with chow and ED, respectively, in the ileum. Changes in gut length, diameter and villus height are significant in each group (p less than .01) but not between groups (p greater than .05).
对80只体重300 - 350克的雄性斯普拉格 - 道利大鼠随机进行85%的肠切除术或空肠活检。恢复后，每组大鼠随机喂食要素饮食（ED）或大鼠饲料。所有大鼠在术后8周处死。活检大鼠食用要素饮食时比食用饲料体重增加更多（22%对18%；p小于0.01）。切除术导致的体重减轻比活检更明显（p小于0.01）且体重增加更缓慢（p小于0.01）。在要素饮食组大鼠中体重未能增加的情况最为明显，到第二周时显著低于饲料组（p小于0.05）。观察到血红蛋白、蛋白质和白蛋白下降：下降情况及两组间差异均无统计学意义（p大于0.05）。接受肠切除术后食用饲料的大鼠比对照组多吃22%（p大于0.05）。切除术后肠长度增加，空肠和回肠增加量相等，食用要素饮食时增加21%，食用饲料时增加26%。切除术后肠直径在食用饲料和要素饮食时分别增加104%和98%。在两个肠切除组的空肠中绒毛高度增加65%，在回肠中，食用饲料和要素饮食时分别增加85%和78%。每组肠长度、直径和绒毛高度的变化均有统计学意义（p小于0.01），但组间无差异（p大于0.05）。
