Arrington P J, McNamara J J
Ann Surg. 1975 Feb;181(2):243-4.
Blood stored at 4 C in ACD or CPD solution develops microaggregates composed primarily of fibrin and platelets. This debris has been implicated in the pathogenesis of posttraumatic pulmonary insufficiency in man. Recent work indicates that gentle agitation of the blood during storage appears to decrease debris formation. These studies were undertaken to establish more clearly the effect of agitation on debris formation. Blood was drawn in CPD from healthy young males, non-aspirin ingesting donors and stored at 4 C. One-half of the bags were gently and continuously agitated for 21 days and the other half remained stationary. At the end of the storage period, platelet counts and screen filtration pressures were measured. Agitated blood showed significantly less debris formation and significantly higher platelet counts. Gentle agitation was shown to be an effective method for preventing debris formation in banked blood.
保存在4摄氏度的ACD或CPD溶液中的血液会形成主要由纤维蛋白和血小板组成的微聚集体。这种碎片与人类创伤后肺功能不全的发病机制有关。最近的研究表明，储存期间对血液进行轻柔搅拌似乎可以减少碎片形成。进行这些研究是为了更清楚地确定搅拌对碎片形成的影响。从健康的年轻男性、未服用阿司匹林的献血者中采集CPD血液，并储存在4摄氏度。一半的血袋持续轻柔搅拌21天，另一半保持静止。储存期结束时，测量血小板计数和筛滤压。搅拌过的血液显示出明显较少的碎片形成和明显较高的血小板计数。轻柔搅拌被证明是防止库存血液中碎片形成的有效方法。
