Cheng H L, Tong Y C, Tzai T S, Weng C L, Ho C L, Yang W H, Lin J S, Chow N H
Department of Urology, Medical College, National Cheng Kung University, Tainan, Taiwan 704, R.O.C.
Oncol Rep. 2001 Jan-Feb;8(1):193-6.
Transitional cell carcinoma of the upper urinary tract is an uncommon neoplasm. Relatively little information is available regarding the clinical relevance of molecular markers. This study was performed to examine the importance of nm23-H1 gene expression (NM23-H1) in this type of tumors. Immunohistochemical expression of NM23-H1 was analyzed in 90 cases of upper urinary tract cancer, and was compared for its prognostic significance with conventional biological indicators. High expression of NM23-H1 was found in 7 cases (8%), intermediate expression in 32 cases (36%), and low expression in 51 cases (57%). Reduced NM23-H1 (defined as intermediate or low level of expression) was associated with a higher histological grading (p=0.002), invasive tumor growth (p=0. 002), or an increased proliferating cell nuclear antigen labeling index (p=0.004). NM23-H1 tended to inversely relate to later recurrence or long-term survival (p=0.06), but, only tumor staging was found to be significant in predicting clinical outcome (p=0.002). nm23-H1 appears to function as a tumor suppressor for upper urinary tract cancer, however, evaluation of NM23-H1 provides limited prognostic information.
上尿路移行细胞癌是一种罕见的肿瘤。关于分子标志物的临床相关性，目前可用的信息相对较少。本研究旨在探讨nm23-H1基因表达（NM23-H1）在这类肿瘤中的重要性。对90例上尿路癌患者的NM23-H1免疫组化表达进行分析，并将其与传统生物学指标的预后意义进行比较。结果发现，7例（8%）患者NM23-H1高表达，32例（36%）患者中等表达，51例（57%）患者低表达。NM23-H1表达降低（定义为中等或低表达水平）与较高的组织学分级（p=0.002）、肿瘤浸润性生长（p=0.002）或增殖细胞核抗原标记指数增加（p=0.004）相关。NM23-H1倾向于与后期复发或长期生存呈负相关（p=0.06），但只有肿瘤分期在预测临床结果方面具有显著性（p=0.002）。nm23-H1似乎对上尿路癌起到肿瘤抑制作用，然而，对NM23-H1的评估提供的预后信息有限。
