Ward C, Hancock B W
Br Heart J. 1975 Jan;37(1):74-8. doi: 10.1136/hrt.37.1.74.
Five hundred and eighty six patients with mitral valve disease were studied with cardiac catheterization between 1961 and 1972; 48 (8.2%) had extreme pulmonary hypertension (resting systolic pulmonary artery pressure of 80 mmHg or above and pulmonary vascular resistance of 10 units or greater) and of these patients, 27 underwent cardiac surgery. The operative mortality for mitral valvotomy was 11 per cent and for mitral valve replacement 56 per cent. The overall mortality was 31 per cent. The risks of operation were increased in those with a long history of cardiac symptoms, those over 50 years of age, and in the presence of associated aortic valve disease. The mean survival for those patients not having operation was only 2.4 plus or minus 0.5 years. The mean follow-up period for those surviving operation has been 5.8 plus or minus 0.6 years, and symptomatic improvement has been good.
1961年至1972年间，对586例二尖瓣疾病患者进行了心导管检查；其中48例（8.2%）患有重度肺动脉高压（静息时收缩期肺动脉压达80mmHg或以上，肺血管阻力为10单位或更高），这些患者中有27例接受了心脏手术。二尖瓣切开术的手术死亡率为11%，二尖瓣置换术为56%。总体死亡率为31%。有长期心脏症状的患者、50岁以上的患者以及存在合并主动脉瓣疾病的患者手术风险增加。未接受手术的患者平均生存期仅为2.4±0.5年。手术存活患者的平均随访期为5.8±0.6年，症状改善良好。
