Launer L J
Epidemiology, Demography, Biometry Program, National Institute on Aging, National Institutes of Health, 7201 Wisconsin Ave, 3C-309, Bethesda, MD 20892 USA.
J Nutr Health Aging. 2000;4(4):197-201.
Experimental studies have identified several pathways through which oxidative stress could adversely affect cognitive function and increase the risk for dementia. Anti-oxidant supplements have been proposed as interventions for secondary or primary prevention against dementia. The existing observational studies and randomized trials examining anti-oxidants and cognitive function outcomes are reviewed. A discussion is provided of methodologic limitations of existing studies and possible directions for future investigations.
实验研究已经确定了氧化应激可能对认知功能产生不利影响并增加患痴呆症风险的几种途径。抗氧化剂补充剂已被提议作为二级或一级预防痴呆症的干预措施。本文综述了现有的观察性研究和检验抗氧化剂与认知功能结果的随机试验。文中讨论了现有研究的方法学局限性以及未来研究可能的方向。
