Siekmeier Rüdiger, Steffen Christian, März Winfried
Federal Institute for Drugs and Medical Devices (BfArM), Bonn, Germany.
J Cardiovasc Pharmacol Ther. 2007 Dec;12(4):265-82. doi: 10.1177/1074248407299519.
Both in vitro and in vivo studies have shown that oxidants are central in the development of atherosclerosis. Consequently, additional studies evaluated the protective effects of various natural and synthetic antioxidants, alone and in combination, with most studies focusing on alpha-tocopherol (vitamin E). Here, we summarize the role of oxidants in the pathomechanism of atherosclerosis. We also discuss epidemiological studies and others focused on the protective effect of vitamin E against atherosclerosis. Other antioxidants are also considered if they were included in studies involving vitamin E. The protective effect of antioxidants on atherosclerotic pathomechanisms has been confirmed in vitro, but only in some animal studies. Various epidemiological and observational studies have produced conflicting results on the protective effect of antioxidants. Most studies of primary or secondary prevention failed to show a protective effect. These conflicting results are biased by a number of factors, including differences between the study groups. Therefore, we describe these studies in detail.
体外和体内研究均表明，氧化剂在动脉粥样硬化的发展过程中起着核心作用。因此，更多研究评估了各种天然和合成抗氧化剂单独或联合使用时的保护作用，大多数研究聚焦于α-生育酚（维生素E）。在此，我们总结了氧化剂在动脉粥样硬化发病机制中的作用。我们还讨论了流行病学研究以及其他关注维生素E对动脉粥样硬化保护作用的研究。如果其他抗氧化剂被纳入涉及维生素E的研究中，我们也会对其进行考量。抗氧化剂对动脉粥样硬化发病机制的保护作用已在体外得到证实，但仅在部分动物研究中得到验证。各种流行病学和观察性研究在抗氧化剂的保护作用方面得出了相互矛盾的结果。大多数一级或二级预防研究未能显示出保护作用。这些相互矛盾的结果受到多种因素的影响，包括研究组之间的差异。因此，我们将详细描述这些研究。
