Dua H S, Saini J S, Azuara-Blanco A, Gupta P
Department of Ophthalmology, Queens Medical Centre, Nottingham, UK.
Indian J Ophthalmol. 2000 Jun;48(2):83-92.
Defects in renewal and repair of ocular surface as a result of limbal stem cell deficiency are now known to cause varying ocular surface morbidity including persistent photophobia, repeated and persistent surface breakdown and overt conjunctivalisation of the cornea. Ocular conditions with abnormalities of ocular surface repair include pterygium, limbal tumours, aniridia, severe scarring following burns, cicatricial pemphigoid and Stevens-Johnson Syndrome, sequelae of mustard gas exposure and Herpes simplex epithelial disease, radiation keratopathy, contact lens induced keratopathy, neuroparalytic keratitis and drug toxicity. Restoring ocular health in these eyes has traditionally been frustrating. An understanding of these intricate cell renewal and maintenance processes has spurred the evolution in recent years of new treatment methods for several blinding diseases of the anterior segment; many more exciting modalities are in the offing. However, there is inadequate awareness among ophthalmologists about the current principles of management of ocular surface disorders. The purpose of this article is to help elucidate the important principles and current treatment methods relevant to ocular surface disorders.
如今已知，由于角膜缘干细胞缺乏导致的眼表更新和修复缺陷会引发各种眼表疾病，包括持续性畏光、反复且持续的眼表破损以及角膜明显结膜化。眼表修复异常的眼部疾病包括翼状胬肉、角膜缘肿瘤、无虹膜、烧伤后严重瘢痕形成、瘢痕性类天疱疮和史蒂文斯 - 约翰逊综合征、芥子气暴露后遗症和单纯疱疹上皮疾病、放射性角膜病变、隐形眼镜引起的角膜病变、神经麻痹性角膜炎和药物毒性。传统上，恢复这些眼睛的眼部健康一直令人沮丧。对这些复杂的细胞更新和维持过程的理解推动了近年来针对几种眼前段致盲疾病新治疗方法的发展；更多令人兴奋的治疗方式即将出现。然而，眼科医生对眼表疾病当前的管理原则认识不足。本文旨在帮助阐明与眼表疾病相关的重要原则和当前治疗方法。
