Korkmaz Ilayda, Sakin Ozer, Palamar Melis, Egrilmez Sait, Yagci Ayse, Barut Selver Ozlem
Department of Ophthalmology, Ege University Medical Faculty Hospital, Ege University, 35100, Bornova, Izmir, Turkey.
Int Ophthalmol. 2025 Jan 24;45(1):34. doi: 10.1007/s10792-024-03389-y.
To evaluate the severity distribution of chemical burn-induced Limbal stem cell deficiency (LSCD) according to the novel global consensus classification and to compare the treatment approach, before and after the global consensus.
Medical records of 127 eyes of 109 patients with LSCD were included. LSCD stages were categorized according to the global consensus classification published by "International LSCD Working Group".
The mean age was 37.5 ± 16.5(6-75). The distribution of LSCD stage according to the global consensus scale was as follows: Stage 1A in 5 eyes(3.9%);Stage 1B in 16 eyes(12.6%);Stage 1C in 4 eyes(3.2%);Stage 2A in 15 eyes(11.8%);Stage 2B in 36 eyes(28.3%);Stage 3 in 51 eyes(40.2%). A total of 88(69.3%) eyes underwent surgery for LSCD. Of these, 80 had surgery prior to the publication of the global consensus (before October 2020), 58(72.5%) had preoperative severe (≥ Stage 2B) LSCD and 22(27.5%) had preoperative early stage (≤ Stage 2A) LSCD. As of October 2020, all 8 eyes that underwent surgery had preoperative severe (≥ Stage 2B) LSCD, as recommended by global consensus.
Recently, a global consensus has been established on both the classification and the management of LSCD. This study is one of the first to present small-scale epidemiological data on the severity distribution of LSCD in the light of the global consensus. It was observed that surgery was performed on 27.5% of the eyes that were not recommended for surgery according to this new consensus. With the increasing awareness of this consensus, it might be possible to avoid unnecessary surgical intervention.
根据新的全球共识分类评估化学烧伤所致角膜缘干细胞缺乏（LSCD）的严重程度分布，并比较全球共识前后的治疗方法。
纳入109例LSCD患者的127只眼的病历。LSCD分期根据“国际LSCD工作组”发布的全球共识分类进行划分。
平均年龄为37.5±16.5（6 - 75岁）。根据全球共识标准，LSCD分期分布如下：1A期5只眼（3.9%）；1B期16只眼（12.6%）；1C期4只眼（3.2%）；2A期15只眼（11.8%）；2B期36只眼（28.3%）；3期51只眼（40.2%）。共有88只眼（69.3%）因LSCD接受手术。其中，80只眼在全球共识发布前（2020年10月之前）接受手术，58只眼（72.5%）术前为重度（≥2B期）LSCD，22只眼（27.5%）术前为早期（≤2A期）LSCD。截至2020年10月，所有8只接受手术的眼术前均为重度（≥2B期）LSCD，这是全球共识所推荐的。
最近，在LSCD的分类和管理方面已达成全球共识。本研究是首批根据全球共识呈现LSCD严重程度分布的小规模流行病学数据的研究之一。据观察，根据这一新共识，27.5%不建议手术的眼接受了手术。随着对这一共识认识的提高，有可能避免不必要的手术干预。
