Donaldson L A, Busuttil A
Br J Surg. 1975 Jan;62(1):26-32. doi: 10.1002/bjs.1800620108.
A clinical and pathological review of 68 patients with a primary carcinoma of the gallbladder was undertaken. A prolonged preceding history of biliary disease was noted. Preoperative radiological and biochemical investigations were not helpful, but an isolated elevation in serum alkaline phosphatase level in the absence of any biliary obstruction or hepatic dysfunction was noticed in some patients. The significance of stones in relation to pathogenesis is discussed. A more radical surgical approach involving a partial hepatectomy appears to be the only possible treatement in veiw of the mode of spread of this tumour and the bad overall prognosis.
对68例原发性胆囊癌患者进行了临床和病理回顾。发现患者之前有长期的胆道疾病史。术前的放射学和生化检查并无帮助，但在一些患者中注意到，血清碱性磷酸酶水平单独升高，而无任何胆道梗阻或肝功能障碍。讨论了结石与发病机制的关系。鉴于该肿瘤的扩散方式和总体预后较差，采用包括部分肝切除术在内的更激进的手术方法似乎是唯一可行的治疗方法。
