Strömland K
Ogonavdelningen för barn, Drottning Silvias barn- och ungdomssjukhus, Sahlgrenska universitetssjukhuset/Ostra, Göteborg.
Lakartidningen. 2000 Nov 8;97(45):5112-3.
One third of Swedes with thalidomide embryopathy have sixth and seventh cranial nerve palsy, named Möbius syndrome/sequence, and some of them suffer from autism. Further, other patients with Möbius sequence have autism. The teratogenic effect of thalidomide on the development of different organ structures occurs early in pregnancy. By studying the birth defects, information can be obtained concerning when the damage occurred. Erroneous development of the sixth and seventh cranial nerves is induced early in pregnancy. The ensuing palsy may be associated with autism. New research is focusing on genes controlling early cranial nerve development.
三分之一患沙利度胺胚胎病的瑞典人患有第六和第七颅神经麻痹，即莫比乌斯综合征/序列，其中一些人患有自闭症。此外，其他患有莫比乌斯序列的患者也患有自闭症。沙利度胺对不同器官结构发育的致畸作用发生在妊娠早期。通过研究出生缺陷，可以获得有关损伤发生时间的信息。第六和第七颅神经的发育异常在妊娠早期就被诱发。随之而来的麻痹可能与自闭症有关。新的研究集中在控制早期颅神经发育的基因上。
