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Human gamma delta T lymphocytes in HIV disease: effector functions and control by natural killer cell receptors.

作者信息

Gougeon M L, Poccia F, Boullier S

机构信息

Unité d'Oncologie Virale, Département SIDA et Rétrovirus, Institut Pasteur, 28 rue du Dr. Roux, 75724 Paris, France.

出版信息

Springer Semin Immunopathol. 2000;22(3):251-63. doi: 10.1007/s002810000046.

DOI:10.1007/s002810000046
PMID:11116956
Abstract
摘要

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Human gamma delta T lymphocytes in HIV disease: effector functions and control by natural killer cell receptors.HIV疾病中的人类γδ T淋巴细胞:效应功能及自然杀伤细胞受体的调控
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2
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3
Leptospira interrogans activation of human peripheral blood mononuclear cells: preferential expansion of TCR gamma delta+ T cells vs TCR alpha beta+ T cells.问号钩端螺旋体对人外周血单个核细胞的激活作用:与TCRαβ⁺ T细胞相比,TCRγδ⁺ T细胞优先扩增
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4
Alternative cytotoxic effector mechanisms in infections with immunodeficiency viruses: gammadelta T lymphocytes and natural killer cells.免疫缺陷病毒感染中的替代性细胞毒性效应机制:γδ T淋巴细胞和自然杀伤细胞。
AIDS. 2000;14 Suppl 3:S175-86.
5
[New insights into cytotoxic effector cells].[细胞毒性效应细胞的新见解]
Bull Cancer. 2005 Nov;92(11):935-43.
6
HIV infection deregulates Tim-3 expression on innate cells: combination antiretroviral therapy results in partial restoration.HIV 感染导致先天细胞上 Tim-3 表达失调:联合抗逆转录病毒疗法可部分恢复。
J Acquir Immune Defic Syndr. 2013 Jun 1;63(2):161-7. doi: 10.1097/QAI.0b013e318285cf13.
7
CD94/NKG2 inhibitory receptor complex modulates both anti-viral and anti-tumoral responses of polyclonal phosphoantigen-reactive V gamma 9V delta 2 T lymphocytes.CD94/NKG2抑制性受体复合物调节多克隆磷酸抗抗原反应性Vγ9Vδ2 T淋巴细胞的抗病毒和抗肿瘤反应。
J Immunol. 1997 Dec 15;159(12):6009-17.
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Do Vgamma2Vdelta2 T cells influence HIV disease progression?Vγ2Vδ2 T细胞会影响HIV疾病进展吗?
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FcgammaRIII discriminates between 2 subsets of Vgamma9Vdelta2 effector cells with different responses and activation pathways.FcγRIII区分具有不同反应和激活途径的Vγ9Vδ2效应细胞的两个亚群。
Blood. 2004 Sep 15;104(6):1801-7. doi: 10.1182/blood-2004-01-0331. Epub 2004 Jun 3.
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Depletion of IL-10- and TGF-beta-producing regulatory gamma delta T cells by administering a daunomycin-conjugated specific monoclonal antibody in early tumor lesions augments the activity of CTLs and NK cells.通过在早期肿瘤病变中给予柔红霉素偶联的特异性单克隆抗体来消耗产生白细胞介素-10和转化生长因子-β的调节性γδT细胞,可增强细胞毒性T淋巴细胞(CTL)和自然杀伤细胞(NK细胞)的活性。
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Immunology. 2017 Aug;151(4):385-394. doi: 10.1111/imm.12735. Epub 2017 May 24.
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High levels of X-linked Inhibitor-of-Apoptosis Protein (XIAP) are indicative of radio chemotherapy resistance in rectal cancer.高水平的X连锁凋亡抑制蛋白(XIAP)表明直肠癌对放化疗具有抗性。
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Natural viral suppressors of HIV-1 have a unique capacity to maintain gammadelta T cells.

本文引用的文献

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NKR-mediated control of gammadelta T-cell immunity to viruses.
Microbes Infect. 1999 Mar;1(3):219-26. doi: 10.1016/s1286-4579(99)80037-9.
2
Recognition of nonpeptide prenyl pyrophosphate antigens by human gammadelta T cells.人类γδ T细胞对非肽类异戊烯焦磷酸抗原的识别。
Microbes Infect. 1999 Mar;1(3):175-86.
3
In vivo gammadelta T cell priming to mycobacterial antigens by primary Mycobacterium tuberculosis infection and exposure to nonpeptidic ligands.原发性结核分枝杆菌感染及接触非肽类配体后,体内γδ T细胞针对分枝杆菌抗原的启动。
天然的 HIV-1 病毒抑制剂具有独特的维持 gammadelta T 细胞的能力。
AIDS. 2009 Sep 24;23(15):1955-64. doi: 10.1097/QAD.0b013e32832ff1ff.
4
Ligand-independent exhaustion of killer immunoglobulin-like receptor-positive CD8+ T cells in human immunodeficiency virus type 1 infection.人类免疫缺陷病毒1型感染中杀伤性免疫球蛋白样受体阳性CD8 + T细胞的配体非依赖性耗竭
J Virol. 2008 Oct;82(19):9668-77. doi: 10.1128/JVI.00341-08. Epub 2008 Jun 25.
5
Development of Vgamma2Vdelta2+ T cell responses during active mycobacterial coinfection of simian immunodeficiency virus-infected macaques requires control of viral infection and immune competence of CD4+ T cells.在猿猴免疫缺陷病毒感染的猕猴发生活动性分枝杆菌合并感染期间,Vγ2Vδ2 + T细胞反应的发展需要控制病毒感染以及CD4 + T细胞的免疫能力。
J Infect Dis. 2004 Oct 15;190(8):1438-47. doi: 10.1086/423939. Epub 2004 Sep 10.
6
Vgamma2Vdelta2+ T cells and anti-microbial immune responses.Vγ2Vδ2 + T细胞与抗微生物免疫反应。
Microbes Infect. 2003 May;5(6):491-8. doi: 10.1016/s1286-4579(03)00074-1.
7
Comparative biology of gamma delta T cells.γδ T细胞的比较生物学
Sci Prog. 2002;85(Pt 4):347-58. doi: 10.3184/003685002783238762.
8
Inhibition of adaptive Vgamma2Vdelta2+ T-cell responses during active mycobacterial coinfection of simian immunodeficiency virus SIVmac-infected monkeys.在感染猿猴免疫缺陷病毒SIVmac的猴子发生活动性分枝杆菌合并感染期间,适应性Vγ2Vδ2 + T细胞反应受到抑制。
J Virol. 2003 Mar;77(5):2998-3006. doi: 10.1128/jvi.77.5.2998-3006.2003.
Mol Med. 1999 Jul;5(7):471-6.
4
Phosphoantigen-reactive Vgamma9Vdelta2 T lymphocytes suppress in vitro human immunodeficiency virus type 1 replication by cell-released antiviral factors including CC chemokines.磷酸抗原反应性Vγ9Vδ2 T淋巴细胞通过包括CC趋化因子在内的细胞释放抗病毒因子在体外抑制1型人类免疫缺陷病毒的复制。
J Infect Dis. 1999 Sep;180(3):858-61. doi: 10.1086/314925.
5
Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA.NKG2D(一种应激诱导的MICA受体)对自然杀伤细胞和T细胞的激活作用。
Science. 1999 Jul 30;285(5428):727-9. doi: 10.1126/science.285.5428.727.
6
Regulation by cytokines (IL-12, IL-15, IL-4 and IL-10) of the Vgamma9Vdelta2 T cell response to mycobacterial phosphoantigens in responder and anergic HIV-infected persons.细胞因子(白细胞介素-12、白细胞介素-15、白细胞介素-4和白细胞介素-10)对有反应和无反应的HIV感染者中Vγ9Vδ2 T细胞对分枝杆菌磷酸抗原反应的调节作用。
Eur J Immunol. 1999 Jan;29(1):90-9. doi: 10.1002/(SICI)1521-4141(199901)29:01<90::AID-IMMU90>3.0.CO;2-1.
7
Phosphoantigen activation induces surface translocation of intracellular CD94/NKG2A class I receptor on CD94- peripheral Vgamma9 Vdelta2 T cells but not on CD94- thymic or mature gammadelta T cell clones.磷酸化抗原激活可诱导细胞内CD94/NKG2A I类受体在CD94阴性外周Vγ9Vδ2 T细胞表面发生易位,但在CD94阴性胸腺或成熟γδ T细胞克隆中则不会。
Eur J Immunol. 1998 Nov;28(11):3399-410. doi: 10.1002/(SICI)1521-4141(199811)28:11<3399::AID-IMMU3399>3.0.CO;2-W.
8
Innate T-cell immunity to nonpeptidic antigens.天然T细胞对非肽类抗原的免疫
Immunol Today. 1998 Jun;19(6):253-6. doi: 10.1016/s0167-5699(98)01266-3.
9
Regulation of KIR expression in human T cells: a safety mechanism that may impair protective T-cell responses.人类T细胞中杀伤细胞免疫球蛋白样受体(KIR)表达的调控:一种可能损害保护性T细胞反应的安全机制。
Immunol Today. 1998 Apr;19(4):153-7. doi: 10.1016/s0167-5699(97)01236-x.
10
IL-15 enhances the response of human gamma delta T cells to nonpeptide [correction of nonpetide] microbial antigens.
J Immunol. 1998 May 1;160(9):4322-9.