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Beta-adrenergic receptors in rat myocardium: direct detection by a new fluorescent beta-blocker.

作者信息

Melamed E, Lahav M, Atlas D

出版信息

Experientia. 1976 Nov 15;32(11):1387-9. doi: 10.1007/BF01937390.

DOI:10.1007/BF01937390
PMID:11117
Abstract

A new fluorescent beta-blocker, 9-amino-acridin propranolol (9-AAP), was administered i.v. to rats. Multiple fluorescent 9-AAP binding sites were observed on cardiac muscle cells in frozen sections. Intensity and density of cardiac 9-AAP fluorescence were markedly reduced following pretreatment with (+/-)- and (-)-propranolol but not with (+)-propranolol. Our findings suggest that 9-AAP may label beta-adrenergic receptor sites in rat myocardium.

摘要

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本文引用的文献

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Direct localisation of beta-adrenoceptor sites in rat cerebellum by a new fluorescent analogue of propranolol.通过心得安的一种新型荧光类似物对大鼠小脑β-肾上腺素能受体位点进行直接定位。
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