Kent W D, Cross-Mellor S K, Kavaliers M, Ossenkopp K P
Neuroscience Program and the Department of Psychology, University of Western Ontario, London, Canada.
Neuroreport. 2000 Nov 27;11(17):3903-8. doi: 10.1097/00001756-200011270-00059.
Previous research has shown that acute corticosterone treatment can have rapid effects on learning and memory. Using the taste reactivity test (TRT), the present study examined the effect of acute administration of corticosterone on sucrose palatability and the development of LiCl-induced rapid gustatory conditioning. On each of two conditioning days rats were injected with either a low dose of lithium chloride (LiCl; 0.75 mEq, i.p.) or saline (NaCl; 0.9%, i.p.) and 10 min later, received a second injection of either corticosterone (5 mg/kg, i.p.) or cyclodextrin vehicle. Rats were then placed in the TRT chamber, where 1 min intraoral infusions of sucrose (0.3 M) were delivered every 10 min. Taste reactivity responses were videotaped and later analyzed for frequency of occurrence. Rats treated with both LiCl and corticosterone showed enhanced aversive responding and reduced ingestive responding relative to control rats treated with LiCl and vehicle. The implication that corticosterone may have a rapid enhancing effect on gustatory conditioning is discussed.
先前的研究表明，急性给予皮质酮可对学习和记忆产生快速影响。本研究采用味觉反应测试（TRT），考察了急性给予皮质酮对蔗糖适口性以及氯化锂诱导的快速味觉条件反射形成的影响。在两个条件反射日中的每一天，给大鼠注射低剂量氯化锂（LiCl；0.75 mEq，腹腔注射）或生理盐水（NaCl；0.9%，腹腔注射），10分钟后，再注射一次皮质酮（5 mg/kg，腹腔注射）或环糊精溶媒。然后将大鼠置于TRT实验箱中，每10分钟进行一次1分钟的口腔内蔗糖（0.3 M）输注。对味觉反应进行录像，随后分析其发生频率。与接受LiCl和溶媒处理的对照大鼠相比，同时接受LiCl和皮质酮处理的大鼠表现出增强的厌恶反应和减少的摄食反应。文中讨论了皮质酮可能对味觉条件反射具有快速增强作用这一观点。
