Cheung C C, Boerner S L, MacMillan C M, Ramyar L, Asa S L
Department of Pathology and Laboratory Medicine and The Freeman Centre in Endocrine Oncology, Mount Sinai Hospital, Toronto, Ontario, Canada.
Am J Surg Pathol. 2000 Dec;24(12):1622-6. doi: 10.1097/00000478-200012000-00005.
Hyalinizing trabecular tumors of the thyroid are interesting but uncommon neoplasms. They have been classified as benign hyalinizing trabecular adenomas or malignant hyalinizing trabecular carcinomas. They share both epidemiologic and morphologic features with papillary carcinoma, and there has been much speculation about the relationship between these two entities. Because RET/PTC gene rearrangements are specific to papillary thyroid carcinoma, the authors examined the presence of RET/PTC-1, -2, and -3 in eight hyalinizing trabecular tumors using reverse transcription-polymerase chain reaction with Southern hybridization and immunohistochemistry. They detected the presence of a RET/PTC gene rearrangement in six of the eight hyalinizing trabecular tumors. This confirms the long-standing suspicion that hyalinizing trabecular tumors do indeed represent a morphologic variant of papillary carcinoma.
甲状腺透明变梁状肿瘤是一类有趣但不常见的肿瘤。它们被分类为良性透明变梁状腺瘤或恶性透明变梁状癌。它们在流行病学和形态学特征上与乳头状癌有共同之处，关于这两种实体之间的关系一直存在很多推测。由于RET/PTC基因重排是甲状腺乳头状癌所特有的，作者使用逆转录-聚合酶链反应结合Southern杂交和免疫组织化学检测了8例透明变梁状肿瘤中RET/PTC-1、-2和-3的存在情况。他们在8例透明变梁状肿瘤中的6例中检测到了RET/PTC基因重排。这证实了长期以来的怀疑，即透明变梁状肿瘤确实代表了乳头状癌的一种形态学变异。
