Ret/PTC1、-2、-3、-δ3和-4在德国甲状腺乳头状癌中的表达
Expression of Ret/PTC1, -2, -3, -delta3 and -4 in German papillary thyroid carcinoma.
作者信息
Mayr B, Pötter E, Goretzki P, Rüschoff J, Dietmaier W, Hoang-Vu C, Dralle H, Brabant G
机构信息
Abteilung Klinische Endokrinologie, Medizinische Hochschule Hannover, Germany.
出版信息
Br J Cancer. 1998 Mar;77(6):903-6. doi: 10.1038/bjc.1998.149.
Abstract
Ret/PTC oncogene has been described with a frequency of 2.5-30% in papillary thyroid carcinomas. We examined the expression of ret/PTC in 99 German papillary thyroid carcinomas, including two recently described new variants of ret/PTC3 and identified eight ret/PTC-positive tumours (8%) but none with the new variants.
摘要
在甲状腺乳头状癌中，Ret/PTC癌基因的检出频率为2.5% - 30%。我们检测了99例德国甲状腺乳头状癌中Ret/PTC的表达情况，其中包括最近描述的Ret/PTC3的两种新变体，结果发现8例Ret/PTC阳性肿瘤（8%），但均未发现新变体。
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