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Ret/PTC1、-2、-3、-δ3和-4在德国甲状腺乳头状癌中的表达

Expression of Ret/PTC1, -2, -3, -delta3 and -4 in German papillary thyroid carcinoma.

作者信息

Mayr B, Pötter E, Goretzki P, Rüschoff J, Dietmaier W, Hoang-Vu C, Dralle H, Brabant G

机构信息

Abteilung Klinische Endokrinologie, Medizinische Hochschule Hannover, Germany.

出版信息

Br J Cancer. 1998 Mar;77(6):903-6. doi: 10.1038/bjc.1998.149.

DOI:10.1038/bjc.1998.149
PMID:9528832
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2150093/
Abstract

Ret/PTC oncogene has been described with a frequency of 2.5-30% in papillary thyroid carcinomas. We examined the expression of ret/PTC in 99 German papillary thyroid carcinomas, including two recently described new variants of ret/PTC3 and identified eight ret/PTC-positive tumours (8%) but none with the new variants.

摘要

在甲状腺乳头状癌中，Ret/PTC癌基因的检出频率为2.5% - 30%。我们检测了99例德国甲状腺乳头状癌中Ret/PTC的表达情况，其中包括最近描述的Ret/PTC3的两种新变体，结果发现8例Ret/PTC阳性肿瘤（8%），但均未发现新变体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5901/2150093/c74369d93e37/brjcancer00082-0054-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5901/2150093/e5a42e791d7f/brjcancer00082-0054-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5901/2150093/c74369d93e37/brjcancer00082-0054-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5901/2150093/e5a42e791d7f/brjcancer00082-0054-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5901/2150093/c74369d93e37/brjcancer00082-0054-b.jpg

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本文引用的文献

1
ret/PTC-1, -2, and -3 oncogene rearrangements in human thyroid carcinomas: implications for metastatic potential?人类甲状腺癌中ret/PTC-1、-2和-3癌基因重排：对转移潜能有何影响？
J Clin Endocrinol Metab. 1997 Apr;82(4):1306-7. doi: 10.1210/jcem.82.4.3891-5.
2
A new form of RET rearrangement in thyroid carcinomas of children after the Chernobyl reactor accident.切尔诺贝利反应堆事故后儿童甲状腺癌中一种新形式的RET重排
Oncogene. 1996 Sep 5;13(5):1099-1102.
3
Molecular and biochemical analysis of RET/PTC4, a novel oncogenic rearrangement between RET and ELE1 genes, in a post-Chernobyl papillary thyroid cancer.
术前分子分析可部分克服细针穿刺活检（FNA）对甲状腺不确定结节的诊断局限性：BRAF和RAS野生型常规空气干燥FNA标本中RET/PTC1重排的评估
Int J Mol Sci. 2017 Apr 12;18(4):806. doi: 10.3390/ijms18040806.
4
Mutation Profile of Well-Differentiated Thyroid Cancer in Asians.亚洲人分化型甲状腺癌的突变特征。
Endocrinol Metab (Seoul). 2015 Sep;30(3):252-62. doi: 10.3803/EnM.2015.30.3.252.
5
Prevalence of RET/PTC1 and RET/PTC3 gene rearrangements in Chennai population and its correlation with clinical parameters.钦奈人群中RET/PTC1和RET/PTC3基因重排的患病率及其与临床参数的相关性。
Tumour Biol. 2014 Oct;35(10):9539-48. doi: 10.1007/s13277-014-1909-x. Epub 2014 Jun 24.
6
RET/PTC Translocations and Clinico-Pathological Features in Human Papillary Thyroid Carcinoma.人甲状腺乳头状癌中的 RET/PTC 易位与临床病理特征。
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8
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切尔诺贝利事故后发生的乳头状甲状腺癌中RET/PTC4（RET基因与ELE1基因之间一种新的致癌重排）的分子和生化分析
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4
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Br J Cancer. 1996 Aug;74(4):585-9. doi: 10.1038/bjc.1996.405.
6
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Cell. 1996 Jun 28;85(7):1113-24. doi: 10.1016/s0092-8674(00)81311-2.
7
Renal and neuronal abnormalities in mice lacking GDNF.缺乏胶质细胞源性神经营养因子的小鼠的肾脏和神经元异常。
Nature. 1996 Jul 4;382(6586):76-9. doi: 10.1038/382076a0.
8
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9
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