Góth L, Eaton J W
Lancet. 2000 Nov 25;356(9244):1820-1. doi: 10.1016/S0140-6736(00)03238-4.
Partial or near-total lack of erythrocyte catalase activity is a rare condition, generally thought to be benign. However, little is known of the frequency of common diseases of adult onset in human beings with catalase deficiency. We report that, in a series of Hungarian patients with catalase deficiency, there is a higher frequency of diabetes than in unaffected first-degree relatives and the general Hungarian population. We speculate that quantitative deficiency of catalase might predispose to cumulative oxidant damage of pancreatic beta-cells and diabetes.
红细胞过氧化氢酶活性部分或近乎完全缺乏是一种罕见病症，通常被认为是良性的。然而，对于过氧化氢酶缺乏的成年人常见疾病的发病频率知之甚少。我们报告称，在一系列匈牙利过氧化氢酶缺乏患者中，糖尿病的发病率高于未受影响的一级亲属和匈牙利普通人群。我们推测，过氧化氢酶的定量缺乏可能易导致胰腺β细胞的累积性氧化损伤及糖尿病。
