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硫代乙酰胺所致肝损伤对大鼠睾丸酮微粒体芳香化作用的影响（作者译）

[Effect of liver damage by thioacetamide on microsomal aromatization of testosterone in rats (author's transl)].

作者信息

Del Pino V L, Bolt H M

出版信息

Experientia. 1976 Nov 15;32(11):1456-7. doi: 10.1007/BF01937431.

DOI:10.1007/BF01937431
PMID:11122
Abstract

Rat liver microsomes, NADPH-regenerating system, and 1beta, 2beta-3H-testosterone have been incubated in vitro. The loss of tritium from the steroid, associated with aromatization of testosterone, was linear with time for 20 min and required NADPH. Pre-treatment of the rats with thioacetamide raised the liberation of tritium from 1beta, 2beta-3H-testosterone. The results suggest that liver damage by thioacetamide in rats may give rise to increased aromatization of testosterone.

摘要

大鼠肝微粒体、NADPH 再生系统和 1β,2β-3H-睾酮已在体外进行孵育。与睾酮芳构化相关的类固醇中氚的损失在 20 分钟内与时间呈线性关系，且需要 NADPH。用硫代乙酰胺对大鼠进行预处理可提高 1β,2β-3H-睾酮中氚的释放。结果表明，硫代乙酰胺对大鼠肝脏的损伤可能导致睾酮芳构化增加。

相似文献

1
[Effect of liver damage by thioacetamide on microsomal aromatization of testosterone in rats (author's transl)].硫代乙酰胺所致肝损伤对大鼠睾丸酮微粒体芳香化作用的影响（作者译）
Experientia. 1976 Nov 15;32(11):1456-7. doi: 10.1007/BF01937431.
2
[Effect of Silymarine-N-methylglucamine salt on the microsomal content of cytochrome P-450 in the rat liver in acute thioacetamide intoxication].[水飞蓟宾-N-甲基葡糖胺盐对急性硫代乙酰胺中毒大鼠肝脏微粒体细胞色素P-450含量的影响]
Experientia. 1974 Nov 15;30(11):1317-8. doi: 10.1007/BF01945206.
3
Proceedings: Studies on hepatic phospholipid metabolism in liver microsomes of rats intoxicated with thioacetamide.
Hoppe Seylers Z Physiol Chem. 1974 Oct;355(10):1225.
4
[The thioacetamide-poisoned rat as an animal experimental model for endocrinological studies of estrogen metabolism in chronic liver injury)].[硫代乙酰胺中毒大鼠作为慢性肝损伤中雌激素代谢内分泌学研究的动物实验模型]
Endokrinologie. 1975 Dec;66(3):250-4.
5
Effects of hepatotoxic agents on hepatic microsomal metabolism of estrogens in the rat.肝毒性药物对大鼠肝脏微粒体雌激素代谢的影响。
Arzneimittelforschung. 1977;27(11):2117-20.
6
[Rat liver collagen in protracted thioacetamide intoxication. 4th communication: Investigations on synthesis and solubility of collagen and the influence of penicillamine (author's transl)].[慢性硫代乙酰胺中毒时大鼠肝脏中的胶原蛋白。第四次通讯：胶原蛋白合成与溶解性的研究以及青霉胺的影响（作者译）]
Arzneimittelforschung. 1978;28(12):2275-81.
7
[Rat liver collagen under protracted thioacetamide intoxication. 1st communication: Collagen fractionation for examining pathologically disturbed collagen metabolism in the liver (author's transl)].[长期硫代乙酰胺中毒时大鼠肝脏的胶原蛋白。第一篇通讯：用于检查肝脏中病理性紊乱胶原蛋白代谢的胶原蛋白分级分离（作者译）]
Arzneimittelforschung. 1979;29(1):71-81.
8
Microsomal activation of thioacetamide-S-oxide to a metabolite(s) that covalently binds to calf thymus DNA and other polynucleotides.硫代乙酰胺 - S - 氧化物经微粒体激活形成一种可与小牛胸腺DNA及其他多核苷酸共价结合的代谢物。
Chem Biol Interact. 1981 Apr;35(1):25-38. doi: 10.1016/0009-2797(81)90061-2.
9
[Hydroxylation of testosterone and 5alpha-dihydrotestosterone--isolation of 2alpha-hydroxytestosterone (author's transl)].睾酮和5α-二氢睾酮的羟基化作用——2α-羟基睾酮的分离（作者译）
Hoppe Seylers Z Physiol Chem. 1976 Aug;357(8):1145-51.
10
[Rat liver collagen in protracted thioacetamide intoxication. 2nd communication: On the determination of collagen-like protein (CLP) and hydroxyproline content in the serum as a parameter of disturbed liver collagen metabolism (author's transl)].[硫代乙酰胺长期中毒时大鼠肝脏中的胶原蛋白。第二篇通讯：血清中类胶原蛋白（CLP）和羟脯氨酸含量的测定作为肝脏胶原蛋白代谢紊乱的一个参数（作者译）]
Arzneimittelforschung. 1979;29(1):82-90.

本文引用的文献

1
Studies on the mechanism of estrogen biosynthesis. VI. The stereochemistry of hydrogen elimination at C-2 during aromatization.雌激素生物合成机制的研究。VI. 芳构化过程中C-2位氢消除的立体化学。
J Am Chem Soc. 1969 Feb 26;91(5):1241-2. doi: 10.1021/ja01033a050.
2
[Inactivation of estradiol by oxidation following liver damage in rats and in patients with liver diseases].
Z Klin Chem Klin Biochem. 1968 Jun;6(4):265-8.
3
[The thioacetamide-poisoned rat as an animal experimental model for endocrinological studies of estrogen metabolism in chronic liver injury)].[硫代乙酰胺中毒大鼠作为慢性肝损伤中雌激素代谢内分泌学研究的动物实验模型]
Endokrinologie. 1975 Dec;66(3):250-4.